Table 1.
Composition and physical characteristics of MbH floating matrix tablets (mg/tablet)
| Formula composition | FT-1 | FT-2 | FT-3 | FT-4 | FT-5 | FT-6 | FT-7 | FT-8 | FT-9 | FT-10 | FT-11 | FT-12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MbH | 200 | 200 | 200 | 200 | 200 | 200 | 200 | 200 | 200 | 200 | 200 | 200 |
| HPMC K15M | 200 | 200 | 200 | – | – | – | 150 | 150 | 150 | – | – | – |
| HPMC K100M | – | – | – | 200 | 200 | 200 | – | – | – | 150 | 150 | 150 |
| Compitrol 888 ATO5 | 100 | – | – | 100 | – | – | 150 | – | – | 150 | – | – |
| Precirol ATO5 | – | 100 | – | – | 100 | – | – | 150 | – | – | 150 | – |
| Glycerol monostearate | – | – | 100 | – | – | 100 | – | – | 150 | – | – | 150 |
| NaHCO3 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 |
| Citric acid | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 |
| FLt (sec) | 34 | 37 | 35 | 40 | 41 | 39 | 28 | 30 | 29 | 34 | 32 | 39 |
| Floating duration (h) | >12 | >12 | >12 | >12 | >12 | >12 | >12 | >12 | >12 | >12 | >12 | >12 |
Note: All floating matrix tablets contain 2% talc and 2% magnesium stearate as a lubricant.
Abbreviations: FT, floating matrix tablet; MbH, Mebeverine HCl; HPMC, hydroxypropyl methycellulose; FLt, floating lag time.