Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Apr 3;12:2657–2672. doi: 10.2147/IJN.S132929

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 Sun et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

Scheme 1 — Compositions of multifunctional DNA nanostructures and schematic illustration of combined biological effect and chemotherapy for colorectal cancer.

Notes: SL2B binds to VEGF165 and inhibits colorectal cancer cells by interfering subsequent VEGF/Notch signaling pathways. DNA TD can enter the nucleus due to its small diameter. Folate interacts with its receptor and enhanced intracellular delivery of DNA nanostructures by receptor-mediated endocytosis. TD releases DOX in the cytoplasm and nucleus to inhibit cell proliferation. The combined therapy of SL2B and DOX ultimately caused enhanced cell death.

Abbreviations: DOX, doxorubicin; TD, tetrahedron; VEGF, vascular endothelial growth factor.