Table S2.

Cell inhibition by TD and TD-2F on HT-29 cells

	65	32.5	6.5	3.25	0.65
CTD (nM)
Inhibition rate (%)
24 h	1.06±0.39	1.36±0.51	2.10±0.24	1.44±0.08	1.87±0.12
48 h	0.72±0.09	1.66±0.34	1.15±12	2.71±0.31	4.19±0.53
72 h	1.88±0.28	0.72±0.45	0.29±0.56	0.4±0.01	2.50±0.37
CTD-2F (nM)
Inhibition rate (%)
24 h	1.42±0.78	1.59±1.03	0.44±0.11	2.66±0.53	2.61±0.52
48 h	3.38±0.89	2.09±0.34	2.59±0.41	1.94±0.12	1.66±0.23
72 h	1.14±0.08	1.69± 0.22	1.67±0.65	2.16±0.26	0.044±0.01

Abbreviations: TD, tetrahedron; F, folic acid.