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. 2015 Mar 23;2(1):2329048X14550067. doi: 10.1177/2329048X14550067

Table 1.

KKH Magnesium Sulfate Dosing Protocol for Refractory Status Epilepticus.

Magnesium Sulphate for Refractory Status Epilepticus
(For patients who are not responsive to standard Status Epilepticus management)
Preparation available in KKH Formulary: 49.3% w/v MgSO4 (10mmol/5mL) 1ml = 2 mmol Mg2+ = 493 mg MgSO4
Target serum level: 2-4 mmol/l Endpoint: Electroencephalographic seizure control
Dosing regimen:

Loading: 50mg/kg over 30 minutes (Max = 4g/dose)
Maintenance: start at 20mg/kg/hr (range 20 mg/kg/hr – 40mg/kg/hr)
Maximum infusion dose: 40mg/kg/hr (Recommended maximum daily dose = 40g/day)
Dilution:
Loading:

Load 50mg/kg MgSO4 (≈ 0.1ml/kg of 49.3% w/v MgSO4) over 30 minutes (Max rate : 150mg/min)
Dilute every 1 ml of 49.3% MgSO4 with 2.5 ml 0.9% NaCl
Maintenance (for CENTRAL LINE):

Dilute 500mg Mg (=1ml 49.3% w/v MgSO4) × Body Weight
with 0.9% NaCl to a total volume of 50 ml
(1ml/hr = 10 mg/kg/hr)
Run between 1ml/hr to 4ml/kg/hr (= 10mg/kg/hr to 40 mg/kg/hr)