Table S1.
Mass spectrometry and MVDA data from identified proteins with a VIP>1
| Protein number | MVDA number | Protein name | Accession number | Biological process | MW/pI | MOWSE score | Number of peptides | % Cov. | VIP | OD CWP (mean ± SD) | OD CON (mean ± SD) | OD ratio (CWP/CON) | Alteration CWP Vs. CON |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1a | 3817 | Ceruloplasmin | P00450 | Iron ion | 122206/5.4 | – | – | – | 1.12 | 178 ± 157 | 62 ± 103 | 2.89 | ↑ |
| 4830 | hemostasis | 92120 | 14 | 15.6 | 1.34 | 355 ± 243 | 98 ± 197 | 3.61 | ↑ | ||||
| 4832 | – | – | – | 1.18 | 268 ± 164 | 121 ± 181 | 2.21 | ↑ | |||||
| 4833 | 1.05e+6 | 10 | 12.5 | 1.33 | 233 ± 164 | 81 ± 109 | 2.86 | ↑ | |||||
| 1b | 4816 | Ceruloplasmin | P00450 | Iron ion | 122206/5.4 | – | – | – | 1.25 | 204 ± 123 | 67 ± 87 | 3.07 | ↑ |
| 4828 | hemostasis | – | – | – | 1.18 | 301 ± 236 | 97 ± 109 | 3.11 | ↑ | ||||
| 3903 | 4.09e+10 | 17 | 20.2 | 1.26 | 382 ± 266 | 119 ± 162 | 3.21 | ↑ | |||||
| 3904 | – | – | – | 1.24 | 315 ± 151 | 132 ± 153 | 2.38 | ↑ | |||||
| 4814 | 1.81e+8 | 17 | 18.7 | 1.07 | 335 ± 270 | 145 ± 169 | 2.31 | ↑ | |||||
| 2a | 4914 | Complement C1r subcomponent | P00736 | Immunity | 80119/5.8 | – | – | – | 1.21 | 111 ± 99 | 28 ± 45 | 4.03 | ↑ |
| 5818 | 4.38 | 4 | 8.4 | 1.11 | 213 ± 181 | 59 ± 94 | 3.61 | ↑ | |||||
| 5819 | 822015 | 12 | 15.4 | 1.24 | 233 ± 153 | 81 ± 110 | 2.89 | ↑ | |||||
| 2b | 4810 | Complement C1r subcomponent | P00736 | Immunity | 80119/5.8 | 2.98E+09 | 10 | 20.6 | 1.23 | 563± 232 | 247 ± 174 | 2.28 | ↑ |
| 5825 | 1.13e+11 | 22 | 33.0 | 1.44 | 488 ± 186 | 246 ± 144 | 1.98 | ↑ | |||||
| 5824 | 1.71e+12 | 19 | 30.6 | 1.07 | 277 ± 125 | 162 ± 94 | 1.70 | ↑ | |||||
| 3 | 5823 | Coagulation factor XIII B chain | P05160 | Metabolic | 75511/6.0 | 5.13e+7 | 13 | 23.9 | 1.19 | 699 ± 353 | 384 ± 199 | 1.82 | ↑ |
| 4 | 6701 | Gelsolin | P06396 | Metabolic | 85698/5.9 | 3.01e+11 | 21 | 37.5 | 1.06 | 1506 ± 463 | 1065 ± 442 | 1.41 | ↑ |
| 6714 | 1.64e+12 | 23 | 40.4 | 1.28 | 2192 ± 582 | 1569 ± 426 | 1.40 | ↑ | |||||
| 5 | 6902 | Complement factor B | P00751 | Immunity | 85534/6.7 | 1.20e+16 | 30 | 49.7 | 1.08 | 2226 ± 507 | 1605 ± 690 | 1.39 | ↑ |
| 6 | 7736 | Serotransferrin | P02787 | Iron ion hemostasis | 77065/6.8 | 7.39e+15 | 29 | 49.1 | 1.06 | 42780 ± 10036 | 54298 ± 12906 | 0.79 | ↓ |
| 7a | 8910 | Plasminogen | P00747 | Metabolic | 90570/7.0 | 9.09e+17 | 29 | 46.5 | 1.16 | 773 ± 340 | 463 ± 237 | 1.67 | ↑ |
| 8912 | – | – | – | 1.35 | 718 ± 286 | 392 ± 205 | 1.83 | ↑ | |||||
| 8823 | 5.94e+12 | 22 | 30.6 | 1.32 | 683 ± 331 | 319 ± 211 | 2.14 | ↑ | |||||
| 8824 | – | – | – | 1.23 | 525 ± 255 | 239 ± 150 | 2.20 | ↑ | |||||
| 7b | 8822 | Plasminogen | P00747 | Metabolic | 90570/7.0 | 6.00e+16 | 30 | 50.4 | 1.08 | 739 ± 327 | 430 ± 292 | 1.72 | ↑ |
| 8821 | – | – | – | 1.00 | 773 ± 326 | 460 ± 352 | 1.68 | ↑ | |||||
| 8 | 1806 | Complement C1s subcomponent | P09871 | Immunity | 76685/4.9 | 169203 | 14 | 21.9 | 1.21 | 628 ± 347 | 259 ± 355 | 2.42 | ↑ |
| 9 | 3704 | Prothrombin | P00734 | Metabolic | 70038/5.6 | 7.65e+12 | 26 | 58.2 | 1.36 | 3602 ± 1269 | 1752 ± 1410 | 2.06 | ↑ |
| 10 | 3712 | Unidentified | – | – | – | – | – | – | 1.07 | 369 ± 161 | 225 ± 132 | 1.64 | ↑ |
| 11 | 3616 | Alpha-2-antiplasmin | P08697 | Metabolic | 54566/5.9 | 239508 | 11 | 30.8 | 1.01 | 220 ± 156 | 94 ± 100 | 2.35 | ↑ |
| 3619 | 12596 | 12 | 28.9 | 1.07 | 822 ± 760 | 414 ± 620 | 1.99 | ↑ | |||||
| 12 | 4503 | Ig alpha-2 chain C region | P01877 | Immunity | 36527/5.7 | 481 | 5 | 18.8 | 1.20 | 6583 ± 3797 | 10969 ± 4475 | 0.60 | ↓ |
| 13 | 2502 | Vitamin D-binding protein | P02774 | Inflammatory | 52964/5.4 | 1.22e+9 | 15 | 33.5 | 1.03 | 3906 ± 2507 | 1946 ± 1240 | 2.01 | ↑ |
| 2403 | 3.03e+6 | 12 | 29.1 | 1.17 | 535 ± 249 | 248 ± 170 | 2.16 | ↑ | |||||
| 3403 | 1.21e+8 | 15 | 41.6 | 1.18 | 738 ± 272 | 453 ± 242 | 1.63 | ↑ | |||||
| 14 | 1526 | Alpha-2-HS-glycoprotein | P02765 | Inflammatory | 39325/5.4 | 7.78e+6 | 9 | 27.5 | 1.52 | 1324 ± 332 | 862 ± 247 | 1.54 | ↑ |
| 15 | 4302 | Fibrinogen gamma chain | P02679 | Metabolic | 51512/5.4 | 3.84e+13 | 19 | 53.4 | 1.28 | 17320 ± 5749 | 11371 ± 3908 | 1.52 | ↑ |
| 4304 | 1.14e+16 | 18 | 59.2 | 1.28 | 25712 ± 8442 | 16721 ± 6137 | 1.54 | ↑ | |||||
| 5302 | 6563 | 8 | 22.5 | 1.09 | 4382 ± 2210 | 2441 ± 1696 | 1.80 | ↑ | |||||
| 16 | 145 | Complement C3c alpha chain fragment 2 | P01024 | Immunity | 39488/4.79 | 6.34e+7 | 15 | 56.0 | 1.56 | 871 ± 301 | 360 ± 299 | 2.42 | ↑ |
| 17 | 1111 | Complement factor I light chain | P05156 | Immunity | 27592/6.24 | 1580 | 6 | 32.0 | 1.51 | 770 ± 328 | 293 ± 273 | 2.63 | ↑ |
| 18 | 3209 | Haptoglobin beta chain | P00738 | Inflammatory | 27265/6.32 | 35609 | 8 | 34.7 | 1.10 | 390 ± 181 | 210 ± 171 | 1.86 | ↑ |
| 19 | 6324 | Ficolin-3 | O75636 | Immunity | 32903/6.2 | 31230 | 6 | 20.1 | 1.06 | 604 ± 330 | 313 ± 271 | 1.93 | ↑ |
| 20 | 6114 | Ig kappa chain C region | P01834 | Immunity | 11609/5.6 | 1139 | 2 | 30.2 | 1.01 | 602 ± 867 | 1733 ± 2089 | 0.35 | ↓ |
| 8001 | 1.69e+6 | 5 | 80.2 | 1.02 | 18099 ± 12404 | 8460 ± 8529 | 2.14 | ↑ | |||||
| 21 | 1102 | Apolipoprotein A-I | P02647 | Metabolic | 30778/5.6 | 2.39e+13 | 19 | 68.9 | 1.07 | 15848 ± 5685 | 22160 ± 6806 | 0.72 | ↓ |
| 22 | 2116 | Transthyretin | P02766 | Metabolic | 15887/5.5 | 97.5 | 4 | 30.0 | 1.13 | 1218 ± 1348 | 3497 ± 2539 | 0.35 | ↓ |
Notes: ↑=upregulated protein. ↓=downregulated protein.
Abbreviations: MVDA, multivariate data analysis; MW, molecular weight; pI, isoelectric point; MOWSE, molecular weight search; Cov., coverage; VIP, variable influence of projection; OD, optical density; CWP, chronic widespread pain; SD, standard deviation; CON, controls.