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. 2016 Nov 28;45(3):1219–1232. doi: 10.1093/nar/gkw1170

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — MLH1 deficiency-induced TSI is independent of p53 or Rb. (A) Western blot of MLH1 knockdown in BJ/hTERT and BJ/E6E7/hTERT cells. Two sequences were used to deplete endogenous MLH1. (B) Telomere-FISH of BJ/hTERT and BJ/E6E7/hTERT cells with MLH1 or control knockdown. White arrows indicate inserted telomeric sequences. (C) Frequency of TSI in BJ/hTERT and BJ/E6E7/hTERT after MLH1 depletion. In each experiment, >1500 chromosomes from each sample were analyzed and each experiment was repeated with three independent replicates.