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. 2016 Nov 28;45(3):1219–1232. doi: 10.1093/nar/gkw1170

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — MLH1 deficiency-induced TSI is dependent on telomerase. (A) Western blot of MLH1 knockdown in BJ/E6E7 cells. (B) Telomere-FISH of BJ/E6E7 cells with MLH1 or control knockdown (LUC). (C) Frequency of TSI in BJ/E6E7 treated with or without etoposide. (D) Frequency of TSI in HCT116 and HCT116^MLH1 treated with or without telomerase inhibitor BIBR1532 (10 μM, 24 h) and etoposide (3 μM, 2 h). In each experiment, >1500 chromosomes from each sample were analyzed and each experiment was repeated with three independent replicates.