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. 2016 Sep 19;45(3):1469–1478. doi: 10.1093/nar/gkw828

Figure 2.

Figure 2.

Biodistribution of ARC-520 RNAi trigger guide strands in mouse tissues. Mice were administered 6 mg/kg ARC-520 or 8 mg/kg API-520, then at 1 h or 96 h post-administration mice were sacrificed and tissues collected. PNA assay was employed to evaluate non-phosphorylated full-length guide strands (non-P FL GS), 5΄-phosphorylated full-length guide strands (5΄ P FL GS) and the combination of non-P FL GS + 5΄ P FL GS + metabolites (Total GS). Quantitation of guide strands was based on a standard curve, and indicated as ng of guide strands per gram of tissue or plasma. (A) AD0009 in liver; (B) AD0010 in liver; (C) AD0009 in spleen; (D) AD0010 in spleen; (E) AD0009 in kidney; (F) AD0010 in kidney; (G) AD0009 in plasma; and (H) AD0010 in plasma.