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. 2016 Sep 19;45(3):1469–1478. doi: 10.1093/nar/gkw828

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© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Kinetics of ARC-520 RNAi trigger guide strand accumulation in mouse liver. Mice were injected with 8 mg/kg ARC-520 and sacrificed at multiple time-points for evaluation of HBV guide strands in liver by PNA assay. Quantitation of guide strands was based on a standard curve, and indicated as ng of guide strands per gram of liver tissue. Guide strands quantitated were AD0009 non-phosphorylated FL (▪), AD0010 non-phosphorylated FL (■), AD0009 5΄-phosphorylated FL (▴) and AD0010 5΄-phosphorylated FL (Δ).