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. 2017 Apr 11;14(4):e1002279. doi: 10.1371/journal.pmed.1002279

Table 3. Number of events and adjusted hazard ratios (95% CIs) for diabetic complications according to five categories of fresh fruit consumption.

Outcome Frequency of fresh fruit consumption ptrend
Never/rarely Monthly 1–3 d/wk 4–6 d/wk Daily
All-cause mortality
Number of events 643 1,090 923 201 532
HR 1.00 0.90 0.91 0.84 0.79 0.002
95% CI 0.92–1.09 0.84–0.96 0.85–0.97 0.73–0.96 0.72–0.87
Diabetes mortality
Number of events 150 181 128 17 36
HR 1.0 0.74 0.79 0.51 0.57 0.008
95% CI 0.84–1.19 0.63–0.87 0.66–0.95 0.32–0.83 0.40–0.81
Cardiovascular mortality
Number of events 265 491 382 82 239
HR 1.00 1.02 0.96 0.86 0.81 0.006
95% CI 0.88–1.14 0.93–1.13 0.87–1.07 0.69–1.08 0.70–0.93
Total macrovasuclar complications
Number of events 1,383 2,842 2,684 717 2,120
HR 1.00 0.95 0.94 0.91 0.86 <0.001
95% CI 0.95–1.06 0.91–0.99 0.90–0.98 0.84–0.98 0.82–0.90
Ischaemic heart disease
Number of events 473 737 844 222 873
HR 1.00 0.89 0.92 0.92 0.88 0.19
95% CI 0.91–1.10 0.82–0.96 0.86–0.98 0.81–1.05 0.82–0.95
Stroke
Number of events 530 947 919 271 715
HR 1.00 0.96 0.96 1.02 0.84 0.004
95% CI 0.91–1.10 0.90–1.04 0.90–1.03 0.90–1.15 0.77–0.91
Other macrovascular events
Number of events 380 1,158 921 224 532
HR 1.00 1.00 0.96 0.85 0.94 0.17
95% CI 0.90–1.11 0.93–1.06 0.90–1.02 0.75–0.97 0.85–1.04
Total microvascular complications
Number of events 234 424 358 78 251
HR 1.00 0.93 0.82 0.69 0.72 <0.001
95% CI 0.87–1.15 0.84–1.04 0.74–0.91 0.55–0.87 0.63–0.83
Nephropathy
Number of events 89 133 111 17 78
HR 1.00 0.89 0.77 0.49 0.69 0.02
95% CI 0.80–1.25 0.74–1.08 0.64–0.93 0.30–0.79 0.53–0.88
Retinopathy
Number of events 83 166 114 23 90
HR 1.00 1.12 0.83 0.67 0.76 0.01
95% CI 0.79–1.26 0.95–1.33 0.69–1.00 0.44–1.02 0.60–0.96
Neuropathy
Number of events 83 167 155 41 105
HR 1.00 0.86 0.82 0.77 0.71 0.05
95% CI 0.73–1.03 0.70–0.96 0.70–0.96 0.56–1.05 0.57–0.88

Analyses were stratified by age at risk, sex, and region and adjusted for education, income, alcohol intake, smoking, physical activity, survey season, body mass index, family history of diabetes, baseline status of diabetes and cardiovascular disease, anti-diabetic treatment, and intakes of dairy products, meat and preserved vegetables. HR, hazard ratio.