Table 2.
Analysis of inactivating mutations of hsaHTenv encoding provirus in human, gorilla and orangutan genomes. Proviral sequences were aligned to the ancestral HERV-T3 sequence. Nonsense mutations and frameshift indels relative to the ancestral sequence were quantified. ‘Indel’ = insertion or deletion events compared to the ancestral HERV-T3 sequence that resulted in a reading frame change. ‘Stop’ = mutations that resulted in a stop codon. (*) Indicates a single nucleotide insertion that results in the truncation of the last five amino acids compared with ancHTenv.
| Locus | Gag (length: 519 codons) | Pol (length: 1206 codons) | Env (length: 631 codons) | |||
|---|---|---|---|---|---|---|
| Indel | Stop | Indel | Stop | Indel | Stop | |
| Human | 4 | 6 | 3 | 16 | (1*) | 0 |
| Gorilla | 4 | 6 | 4 | 15 | 1 (1*) | 0 |
| Orangutan | 5 | 9 | 3 | 15 | (1*) | 0 |