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The 5-LOX/COX-2 crossover pathway. Consecutive transformation of arachidonic acid by 5-LOX and COX-2 yielded the hemiketal (HK) eicosanoids HKD2 and HKE2 as well as the by-products 5,11- and 5,15-diHETE. The oxygen atoms introduced in the enzymatic reactions are color-coded to illustrate their origin and fate during the transformations.
