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. 2017 Feb 1;31(5):2076–2089. doi: 10.1096/fj.201601155R

Figure 2.

Figure 2.

Protective effect of FPS-ZM1 against PPE-induced experimental COPD. PPE was applied once through intratracheal injection on d 14, and FPS-ZM1 was applied through intraperitoneal injection daily for 14 d. A) Representative images of H&E-stained lung sections (n = 4 per group) in mice exposed to saline or PPE, with or without administration of FPS-ZM1. Original magnification, ×100. Scale bars, 200 μm. B) Airspace enlargement was quantified by the mean linear intercept (Lm) values of alveoli (n = 4 per group). Values represent the means ± sd. C) Total cell counts in BALF (n = 3 per group). D) Macrophage, neutrophil and lymphocyte counts in BALF (n = 3 per group). E, F) Quantification of BALF (E) IL-6 and TNF-α (F) protein concentrations in mice (n = 3 per group, ELISA). G) Nitrite levels in the BALF (n = 3 per group, Griess assay). H) Total intracellular SOD activity in the lung homogenate (n = 4 per group). I, J) Levels of GSH (I) and GSSG (J) in the lung homogenate (n = 4 per group). Ctl, control group. *P < 0.05, **P < 0.01, ***P < 0.001 vs. controls; †P < 0.05, ††P < 0.01, †††P < 0.001 vs. PPE-induced mice.