TABLE 4.
Duration of induced defensin resistancea
| Defensin challenge (50 μg/ml) | Mean log10 no. of bacteria 36 h after:
|
||||||
|---|---|---|---|---|---|---|---|
| Pretreatment with 1 ng of hβD-2/ml
|
No pretreatment
|
||||||
| 0b | 30 | 60 | 90 | 120 | 0 | 120 | |
| None | 7.73 | 7.89 | 7.92 | 7.51 | 7.32 | 7.64 | 7.97 |
| hβD-1 | 6.94 | NDc | ND | 7.00 | 5.16d | 6.12e | 5.27e |
| hβD-2 | 7.26 | 8.10 | 7.49 | 6.78 | 5.34d | 5.05e | 5.25e |
| hβD-3 | 8.03 | ND | ND | 7.07 | 5.81d | 5.21e | 5.04e |
| hβD-4 | 7.37 | ND | ND | 7.17 | 5.08d | 5.36e | 5.61e |
a
n = 12 at each point.
b
Time (minutes) posttreatment when defensin was added.
c
ND, not done.
d
P ≤ 0.05, t test compared to previous time point.
e
P ≤ 0.05, t test compared to no-pretreatment, no-challenge control.