TABLE 1.
Representative ingenuity pathways enriched in genes with HG-induced CBP and HAC peaks
| Canonical pathway | -log(P) | Count | Ratio |
|---|---|---|---|
| EIF2 signaling | 14.50 | 88/183 | 0.481 |
| Regulation of eIF4 and p70S6K signaling | 12.40 | 71/145 | 0.490 |
| PI3K/AKT signaling | 11.00 | 61/123 | 0.496 |
| mTOR signaling | 10.20 | 80/186 | 0.430 |
| Cell cycle: G1/S checkpoint regulation | 10.10 | 38/64 | 0.594 |
| Insulin receptor signaling | 9.42 | 61/132 | 0.462 |
| ERK/MAPK signaling | 7.19 | 73/187 | 0.390 |
| Mitochondrial dysfunction | 7.11 | 68/171 | 0.398 |
| PKA signaling | 6.87 | 128/386 | 0.332 |
| NRF2-mediated oxidative stress response | 6.13 | 68/180 | 0.378 |
| Cyclins and cell-cycle regulation | 5.83 | 36/78 | 0.462 |
| Cell cycle: G2/M DNA damage checkpoint regulation | 5.79 | 26/49 | 0.531 |
| Apoptosis signaling | 5.11 | 38/89 | 0.427 |
| ErbB2-ErbB3 signaling | 4.27 | 26/57 | 0.456 |
| Oxidative phosphorylation | 4.27 | 42/109 | 0.385 |
| TGF-β signaling | 4.10 | 35/87 | 0.402 |
| TCA cycle II (eukaryotic) | 3.52 | 13/23 | 0.565 |
| STAT3 pathway | 3.01 | 28/73 | 0.384 |
| NF-κB activation by viruses | 2.66 | 27/73 | 0.370 |
EIF2, eukaryotic initiation factor 2; mTOR, mammalian target of rapamycin; NRF2, nuclear factor erythroid 2-related factor 2; STAT, signal transducers and activators of transcription.