Table 1.

Phenotype of affected individuals in four families with bipolar disorder

	N=15, %
Age, years (SD)	38.4 (15.6)
Age of onset of bipolar disorder, years (SD)	18.2 (7.7)
Gender, male	3 (20)
Diagnosis of bipolar disorder type 1,	14 (93)
Rapid cycling	8 (53)
Suicide attempts	10 (67)
Psychosis	10 (67)
Psychiatric comorbidity
Anxiety disorder	11 (73)
Attention deficit hyperactivity disorder	6 (40)
Substance use disorder	9 (60)
Obsessive compulsive disorder	4 (27)
Antisocial personality disorder	3 (20)
Medical comorbidity
Seizure disorder	5 (33)
Migraine	10 (67)
Disorders of the endocrine system	3 (20)
Disorders of the metabolic system	2 (13)
Disorders of the cardiovascular system	1 (7)
Disorders of the gastrointestinal system	3 (20)
Learning disability	6 (40)
Sleep disorder	4 (27)
Eating disorder	3 (20)