Table 2.
List of mutated genes in bipolar disorder families
| Entrez # | Gene | Name | Function |
|---|---|---|---|
| 9743 | ARHGAP32 | Rho GTPase activating protein 32 | GTPase activator activity (GO:0005096), phosphatidylinositol binding (GO:0035091) |
| 60314 | C12orf10 | chromosome 12 open reading frame 10 | locomotory exploration behavior (GO:0035641) |
| 84516 | DCTN5 | dynactin 5 (p25) | Centrosome (GO:0005813) |
| 2060 | EPS15 | epidermal growth factor receptor pathway substrate 15 | calcium ion binding (GO:0005509) protein binding (GO:0005515) |
| 2568 | GABRP | Gamma-Aminobutyric Acid (GABA) A Receptor, Pi | GABA-A receptor activity (GO:0004890) |
| 115399 | LRRC56 | leucine rich repeat containing 56 | unknown |
| 4649 | MYO9A | myosin IXA | regulation of small GTPase mediated signal transduction (GO:0051056) |
| 84700 | MYO18B | myosin XVIIIB | vasculogenesis (GO:0001570) |
| 284434 | NWD1 | NACHT and WD repeat domain containing 1 | ATP binding (GO:0005524) |
| 5286 | PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 1-phosphatidylinositol-3-kinase activity (GO:0016303) |
| 4660 | PPP1R12B | Protein Phosphatase 1, Regulatory Subunit 12B | small GTPase mediated signal transduction (GO:0007264) |
| 5829 | PXN | Paxillin | activation of MAPK activity (GO:0000187) |
| 374403 | TBC1D10C | TBC1 domain family, member 10C | regulation of Rab GTPase activity (GO:0032313) |
| 7158 | TP53BP1 | tumor protein p53 binding protein 1 | RNA polymerase II activating transcription factor binding (GO:0001102) |
| 143630 | UBQLNL | ubiquilin-like | protein binding (GO:0005515) |
| 146862 | UNC45B | Unc-45 Homolog B (C. Elegans) | chaperone-mediated protein folding (GO:0061077) |