Skip to main content
. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Biochim Biophys Acta. 2016 Oct 11;1862(11):1386–1393. doi: 10.1016/j.bbalip.2016.10.004

Figure 4. Maintenance of OM asymmetry.

Figure 4

Shown are three systems in E. coli that facilitate removal of mislocalized phospholipids from the outer leaflet. The OM phospholipase, PldA, processively degrades mislocalized PLs. The Mla system is comprised of components in each cellular compartment (MlaA,B,C,D,E,F) that collectively facilitate retrograde PL trafficking. The palmitoyltransferase, PagP, also uses mislocalized PLs as a substrate, and transfers an acyl chain to lipid A. The resultant heptaacylated LPS contributes to OM stability and the lyso-PL by-products can presumably be recycled.