Table 4.
Identification of transcription factor binding sites (TFBS) within the human IDS gene promoter
| TFBS | Strand | Chr 1 Position | Function/role | Sequence | UNIPROT ID |
|---|---|---|---|---|---|
| BACH2 | (+ve) | X:148,585,129–139 | Binds to Maf recognition elemants |
GCTGAGTCATG |
Q9BYV9 |
| AP1 | (−ve) | X:148,585,128–140 | Regulating cells forming the skeleton |
GCATGACTCAGCT |
P01101 |
| NFE2 | (+ve) | X:148,585,128–138 | Regulating erythroid maturation | AGCTGAGTCAT | Q16621 |
| BACH1 | (+ve) | X:148,585,127–141 | Coordinates transcription by MAFK | TAGCTGAGTCATGCA | O14867 |
| XBP1 | (+ve) | X:148,584,868–884 | Regulation during ER stress | ATGGTCACATAGCCATT | P17861 |
The identification of TFBS within the IDS promoter region was undertaken using the human genome browser (http://genome.ucsc.edu); UNIPROT refers to UniprotKB/Swiss-Prot IDs for individual TFBS sequences (see http://kr.expasy.org); ER refers to endoplasmic reticulum