FIG. 4.

Morphological studies of HIV-1 virions produced from untreated or G-NH₂-treated cells and analyzed with TEM. (a) Wild-type HIV-1 showing characteristic dense, cone-shaped core (left) and round, centrally placed tangential sections (middle and right); (b) HIV-1 treated with 100 μM G-NH₂ showing empty, multiple core structures (right); (c) HIV-1 treated with 100 μM G-NH₂ showing a double core (left and above) and distorted core structure (right); (d) HIV-1 treated with 100 μM G-NH₂ showing an elongated core in an enlarged virus envelope (below), a hollow core (left above), and a double core structure (right). Bars, 100 nm.