TABLE 1.

IC₅₀s of fagaronine and various Fagara fractions obtained from 48 h in vitro cultures of P. falciparum

Fractiona	IC50 ± SD (μg/ml)
Crude extract	4.9 ± 0.6
First separation
Fractions 1-3	No activity
Fraction 4	1 ± 0.02
Second separation
Fractions 1-2 and 4-7	No activity
Fraction 3	0.13 ± 0.03
Pure fagaronine	0.018

^aA chromatogram for fractions 1 to 4 from the first separation is shown in Fig. 2A. A chromatogram for fractions 1 to 7 from the second separation is shown in Fig. 2C. A chromatogram for pure fagaronine is shown in Fig. 2B.