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. 2005 Jan;49(1):264–268. doi: 10.1128/AAC.49.1.264-268.2005

TABLE 1.

IC50s of fagaronine and various Fagara fractions obtained from 48 h in vitro cultures of P. falciparum

Fractiona IC50 ± SD (μg/ml)
Crude extract 4.9 ± 0.6
First separation
    Fractions 1-3 No activity
    Fraction 4 1 ± 0.02
Second separation
    Fractions 1-2 and 4-7 No activity
    Fraction 3 0.13 ± 0.03
Pure fagaronine 0.018
a

A chromatogram for fractions 1 to 4 from the first separation is shown in Fig. 2A. A chromatogram for fractions 1 to 7 from the second separation is shown in Fig. 2C. A chromatogram for pure fagaronine is shown in Fig. 2B.