Figure 1.

Effects of GCV treatment on ablation of adult-born neurons in the dentate gyrus of TK-1 and TK-2 mice. (A) Representative photomicrographs of DCX⁺ cells and Ki67⁺ cells in the dentate gyrus of TK-1 and TK-2 mice with GCV treatment at 0, 10, 20, 40 mg kg⁻¹ per day. Scale bar, 200 μm. (B,C) Quantification of the number of DCX positive cells in the dentate gyrus of TK-1 mice (n = 3 mice, 5 brain slices for each mouse) and TK-2 mice (n = 3 mice, 5 brain slices for each mouse) with GCV treatment at 0, 10, 20, 40 mg kg⁻¹ per day. (D,E) Quantification of the number of Ki67 positive cells in the dentate gyrus of TK-1 mice (n = 3 mice, 5 brain slices for each mouse) and TK-2 mice (n = 3 mice, 5 brain slices for each mouse) with GCV treatment at 0, 10, 20, 40 mg kg⁻¹ per day. Data represent mean ± SEM,^*P < 0.05, ^***P < 0.001 (one-way ANOVA with post hoc Turkey's multiple comparison test).