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. 2017 Apr 12;8:220. doi: 10.3389/fphys.2017.00220

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Copyright © 2017 Yang, Ahmari, Schmidt, Redler, Arocha, Pacholec, Magee, Malphurs, Owen, Krane, Li, Wang, Vickroy, Raizada, Martyniuk and Zubcevic.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Altered gut microbiota in the b1/2-ARs KO chimera. (A) No significant difference in gut microbiota richness or diversity between the b1/2-ARs KO chimera and C57 control chimera. However, the Firmicutes to Bacteroidetes (F/B) ratio was significantly lower in the b1/2-ARs KO chimera compared to the C57 control chimera. (B) The decreased F/B ratio is attributed to the significant expansion of Bacteroidetes and contraction of Firmicutes. (C) Unweighted Principal coordinate analysis (PCoA) demonstrated a clear separation of red and blue clusters representing C57 and b1/2-ARs KO chimera groups, respectively. ^** indicates P < 0.01.