Table 1.
Clinical studies of microbiome associations and interventions in inflammatory conditions.
| Condition | Longitudinal cohort studies | Case–control studies | Cross-sectional studies | Interventional |
|---|---|---|---|---|
| Inflammatory bowel diseases | (14) (n = 227) | (61) (n = 31) | ||
| Ulcerative colitis | (60) (n = 59), (64) (n = 19), (66) (n = 29), (67) (n = 105), (17) (n = 120), (18) (n = 327), (19) (n = 120), (20) (n = 100), (21) (n = 90), (22) (n = 40), (23) (n = 26), (24) (n = 15), (26) (n = 29), (27) (n = 90), (29) (n = 144), (28) (n = 147), (30) (n = 40), (31) (n = 20), (32) (n = 30), (33) (n = 30), (34) (n = 32), (68) (n = 18), (69) (n = 41), (76) (n = 9), (77) (n = 11), (79) (n = 11), (80) (n = 8), (81) (n = 6), (82) (n = 5), (83) (n = 6), (88) (n = 3), (84) (n = 62), (89) (n = 75), (90) (n = 48), (78) (n = 1), (85) (n = 1) | |||
| Pouchitis | (65) (n = 20), (43) (n = 12), (45) (n = 20), (36) (n = 40), (38) (n = 40), (37) (n = 36), (39) (n = 31), (41) (n = 43), (42) (n = 16), (40) (n = 31) | |||
| Crohn’s disease | (15) (n = 38), (16) (n = 21) | (59) (n = 22), (62) (n = 10), (63) (n = 103), (46) (n = 20), (47) (n = 32), (48) (n = 34), (49) (n = 165), (50) (n = 120), (54) (n = 119), (55) (n = 30), (52) (n = 11), (53) (n = 75), (51) (n = 37), (56) (n = 28), (57) (n = 98), (58) (n = 70), (70) (n = 30), (71) (n = 10), (72) (n = 4), (73) (n = 30), (74) (n = 4), (75) (n = 5), (86) (n = 8), (87) (n = 19) | ||
| Multiple sclerosis | (132) (n = 78), (133) (n = 67), (134) (n = 40), (135) (n = 15), (136) (n = 103), (137) (n = 24), (139) (n = 61) | (138) (n = 17) | (141) (n = 12), (142) (n = 5), (140) (n = 3) | |
| Guillain–Barré syndrome | (145) (n = 171), (146) (n = 103), (147) (n = 212), (148) (n = 549) | (144) (n = 56) | ||
| Fibromyalgia | (151) (n = 95), (152) (n = 114), (154) (n = 100), (155) (n = 233), (156) (n = 1,125), (157) (n = 251), (158) (n = 168) | (153) (n = 233) | ||
| Systemic lupus erythematosus | (161) (n = 40), (162) (n = 35) | |||
| Atherosclerosis | (98) (n = 2,595), (99) (n = 4,007) | (92) (n = 17), (91) (n = 2), (93) (n = 49), (96) (n = 7) | ||
| Vasculitis | (94) (n = 38), (95) (n = 31), (100) (n = 17) | |||
| Eczema | (103) (n = 23) | |||
| Scleroderma | (112) (n = 4), (110) (n = 80) | |||
| Psoriasis | (106) (n = 6), (107) (n = 22), (108) (n = 9,295) | |||
| Rheumatoid arthritis | (114) (n = 30), (117) (n = 83), (116) (n = 156), (118) (n = 114), (113) (n = 212) | (115) (n = 46) | ||
| Asthma | (121) (n = 321), (124) (n = 411), (125) (n = 47), (126) (n = 319) | (120) (n = 43), (122) (n = 20), (123) (n = 51) |