Table 1.
Global all-age DALYs and age-standardised DALY rates in 2005 and 2015 with median percentage change between 2005 and 2015 for all causes
|
All-age DALYs (thousands) |
Age-standardised rate (per 100 000) |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 2005 | 2015 | Percentage change, 2005–15 | 2005 | 2015 | Percentage change, 2005–15 | ||||
| All causes | 2 553 306·8 (2 373 137·6 to 2 756 328·0) | 2 464 895·4 (2 259 889·0 to 2 696 510·8) | −3·5 (−5·3 to −1·8)* | 41 561·7 (38 640·8 to 44 850·4) | 34 445·7 (31 603·0 to 37 654·3) | −17·1 (−18·7 to −15·7)* | |||
| Communicable, maternal, neonatal, and nutritional diseases | 968 014·5 (931 809·4 to 1 012 327·9) | 741 595·9 (703 928·7 to 787 659·9) | −23·4 (−25·2 to −21·7)* | 14 297·6 (13 766·0 to 14 955·1) | 10 007·2 (9 498·5 to 10 629·3) | −30·0 (−31·6 to −28·5)* | |||
| HIV/AIDS and tuberculosis | 148 685·6 (141 013·7 to 160 635·2) | 106 991·8 (99 680·8 to 116 789·9) | −28·0 (−30·6 to −25·1)* | 2296·0 (2172·7 to 2490·5) | 1 435·5 (1 336·0 to 1 569·2) | −37·5 (−39·6 to −35·0)* | |||
| Tuberculosis | 49 769·6 (43 196·4 to 60 348·2) | 40 302·2 (34 065·8 to 49 653·9) | −19·0 (−24·2 to −13·6)* | 817·0(708·5 to 990·9) | 552·4(467·2 to 681·3) | −32·4(−36·7 to −27·9)* | |||
| HIV/AIDS | 98 916·1(94 515·6 to 103 953·2) | 66 689·5 (63 342·9 to 70 788·3) | −32·6 (−35·2 to −29·5)* | 1478·9 (1414·0 to 1553·2) | 883·1 (839·2 to 937·1) | −40·3 (−42·6 to −37·5)* | |||
| HIV/AIDS—tuberculosis | 19 327·0 (15 512·5 to 22 015·1) | 11 621·9 (8 955·5 to 13 412·3) | −39·9 (−44·2 to −34·5)* | 289·6 (232·8 to 329·8) | 154·0 (118·7 to 177·7) | −46·8 (−50·7 to −42·1)* | |||
| HIV/AIDS resulting in other diseases | 79 589·0 (74 869·9 to 85 308·1) | 55 067·6 (51 480·9 to 59 294·3) | −30·8 (−34·2 to −26·9)* | 1189·3 (1119·8 to 1277·1) | 729·1 (681·9 to 784·8) | −38·7 (−41·7 to −35·3)* | |||
| Diarrhoea, lower respiratory, and other common infectious diseases | 333 534·0 (317 202·5 to 351 569·5) | 242 875·8 (230 350·0 to 255 919·1) | −27·2 (−30·2 to −24·2)* | 5005·5 (4769·5 to 5269·7) | 3326·2 (3158·6 to 3503·4) | −33·5 (−36·2 to −30·9)* | |||
| Diarrhoeal diseases | 98 394·2 (90 909·6 to 106 634·4) | 71 589·5 (66 442·9 to 77 205·8) | −27·2 (−33·2 to −20·8)* | 1479·8 (1371·9 to 1598·4) | 976·9 (908·1 to 1 052·7) | −34·0 (−39·3 to −28·4)* | |||
| Intestinal infectious diseases | 15 062·4 (8 707·5 to 24 651·4) | 12 632·0 (7 250·5 to 20 762·5) | −16·1 (−22·9 to −9·9)* | 216·0 (124·9 to 353·2) | 170·8 (98·2 to 280·7) | −20·9 (−27·3 to −14·9)* | |||
| Typhoid fever | 12 543·9 (6 953·1 to 21 143·4) | 10 575·6 (5 896·1 to 17 598·0) | −15·7 (−22·7 to −9·3)* | 179·8 (99·7 to 302·9) | 143·0 (79·8 to 237·7) | −20·5 (−26·9 to −14·2)* | |||
| Paratyphoid fever | 2393·2 (1119·8 to 4569·5) | 2014·8 (960·5 to 3848·4) | −15·8 (−24·2 to −7·4)* | 34·4 (16·1 to 65·6) | 27·2 (13·0 to 52·0) | −20·8 (−28·7 to −12·6)* | |||
| Other intestinal infectious diseases | 125·4 (39·3 to 243·9) | 41·5 (16·3 to 81·3) | −66·9 (−78·0 to −47·0)* | 1·8 (0·6 to 3·5) | 0·6 (0·2 to 1·1) | −69·3 (−79·5 to −51·6)* | |||
| Lower respiratory infections | 135 293·2 (127 083·7 to 143 499·4) | 103 048·6 (96 128·2 to 109 078·8) | −23·8 (−28·2 to −19·4)* | 2 070·3 (1 939·4 to 2 189·6) | 1428·5 (1330·5 to 1511·1) | −31·0 (−34·8 to −27·1)* | |||
| Upper respiratory infections | 2 661·2 (1 550·4 to 4 406·1) | 2868·4 (1650·2 to 4785·2) | 7·8 (5·2 to 9·7)* | 40·1 (23·5 to 66·4) | 38·7 (22·3 to 64·5) | −3·5 (−5·6 to −2·1)* | |||
| Otitis media | 3444·4 (2276·8 to 5004·0) | 3497·6 (2284·9 to 5088·5) | 1·5 (−1·3 to 4·1) | 50·9 (33·7 to 74·1) | 47·3 (30·9 to 68·7) | −7·2 (−9·9 to −4·9)* | |||
| Meningitis | 28 394·6 (24 170·2 to 32 237·2) | 25 394·6 (21 653·2 to 30 649·0) | −10·6 (−20·1 to 3·8) | 416·8 (355·2 to 471·9) | 342·4 (292·3 to 412·8) | −17·8 (−26·4 to −4·6)* | |||
| Pneumococcal meningitis | 7826·5 (6404·7 to 9672·3) | 7773·4 (6353·4 to 9900·2) | −0·7 (−11·2 to 14·9) | 115·3 (94·8 to 141·6) | 104·9 (85·9 to 133·4) | −9·0 (−18·5 to 5·3) | |||
| Haemophilus influenzae type B meningitis | 8507·6 (6656·5 to 10590·4) | 5345·7 (4146·7 to 7103·2) | −37·2 (−45·8 to −25·0)* | 123·3 (96·7 to 153·4) | 71·9 (55·9 to 95·4) | −41·7 (−49·7 to −30·5)* | |||
| Meningococcal meningitis | 5239·8 (4012·0 to 6704·3) | 5065·6 (3879·5 to 6721·8) | −3·3 (−16·9 to 16·3) | 76·6 (59·0 to 97·6) | 68·2 (52·3 to 90·3) | −11·0 (−23·4 to 6·9) | |||
| Other meningitis | 6820·7 (5665·6 to 8234·7) | 7210·0 (5953·9 to 8958·4) | 5·7 (−4·6 to 20·3) | 101·7 (84·9 to 122·0) | 97·4 (80·5 to 120·9) | −4·2 (−13·1 to 9·0) | |||
| Encephalitis | 8850·1 (8064·3 to 9665·8) | 8452·5 (7668·6 to 9411·6) | −4·5 (−11·6 to 2·9) | 132·1 (120·8 to 144·2) | 114·6 (104·0 to 127·6) | −13·2 (−19·7 to −6·8)* | |||
| Diphtheria | 443·2 (229·3 to 905·0) | 170·8 (83·4 to 388·7) | −61·5 (−86·1 to 3·5) | 6·4 (3·3 to 13·1) | 2·3 (1·1 to 5·2) | −64·2 (−87·1 to −3·7)* | |||
| Whooping cough | 8559·1 (3269·5 to 19234·7) | 5070·5 (1815·7 to 10791·8) | −40·8 (−77·3 to 62·2) | 123·2 (47·0 to 276·7) | 68·0 (24·3 to 144·7) | −44·8 (−78·8 to 51·2) | |||
| Tetanus | 7213·2 (6251·3 to 9082·1) | 3510·0 (3002·2 to 4502·9) | −51·3 (−58·0 to −43·8)* | 105·1 (90·6 to 134·4) | 47·1 (40·3 to 60·6) | −55·1 (−61·2 to −48·1)* | |||
| Measles | 24 602·4 (9 272·8 to 51 178·0) | 6150·1 (2193·1 to 13467·4) | −75·0 (−84·4 to −59·0)* | 355·1 (133·9 to 738·2) | 82·7 (29·5 to 181·1) | −76·7 (−85·5 to −61·8)* | |||
| Varicella and herpes zoster | 616·0 (521·8 to 727·1) | 491·2 (386·1 to 625·3) | −20·3 (−33·2 to −4·3)* | 9·7 (8·2 to 11·5) | 6·8 (5·3 to 8·6) | −29·9 (−40·6 to −16·7)* | |||
| Neglected tropical diseases and malaria | 116 583·6 (96 865·6 to 137 551·5) | 79 212·2 (63 820·2 to 97 299·0) | −32·1 (−40·2 to −23·7)* | 1710·8 (1422·4 to 2019·1) | 1066·4 (859·1 to 1310·2) | −37·7 (−45·1 to −30·1)* | |||
| Malaria | 90 438·1 (73 336·5 to 107 546·9) | 55 769·6 (42 478·4 to 69 078·5) | −38·3 (−48·1 to −27·8)* | 1315·8 (1067·0 to 1562·5) | 749·3 (571·0 to 927·9) | −43·1 (−52·0 to −33·4)* | |||
| Chagas disease | 243·6 (220·0 to 273·5) | 236·1 (211·8 to 265·3) | −3·0 (−8·5 to 3·0) | 4·4 (4·0 to 5·0) | 3·4 (3·1 to 3·9) | −22·7 (−27·0 to −18·0)* | |||
| Leishmaniasis | 1367·1 (878·4 to 1979·8) | 1418·9 (1005·8 to 1913·8) | 3·8 (−8·6 to 19·3) | 20·1 (13·0 to 28·9) | 18·9 (13·4 to 25·5) | −5·9 (−16·9 to 8·0) | |||
| Visceral leishmaniasis | 1334·4 (844·9 to 1949·5) | 1377·4 (965·4 to 1863·8) | 3·2 (−9·2 to 19·1) | 19·6 (12·4 to 28·5) | 18·3 (12·9 to 24·8) | −6·3 (−17·4 to 7·9) | |||
| Cutaneous and mucocutaneous leishmaniasis | 32·6 (15·2 to 63·3) | 41·5 (19·4 to 81·0) | 27·3 (23·6 to 30·6)* | 0·5 (0·2 to 1·0) | 0·6 (0·3 to 1·1) | 11·4 (8·2 to 14·5)* | |||
| African trypanosomiasis | 803·1 (425·6 to 1311·4) | 202·4 (104·6 to 322·3) | −74·8 (−80·4 to −68·2)* | 11·8 (6·3 to 19·3) | 2·7 (1·4 to 4·3) | −77·2 (−82·3 to −71·3)* | |||
| Schistosomiasis | 3417·7 (1883·7 to 6044·0) | 2613·3 (1409·9 to 4695·8) | −23·5 (−30·6 to −6·7)* | 51·1 (28·4 to 90·0) | 35·1 (19·0 to 62·9) | −31·3 (−37·7 to −16·2)* | |||
| Cysticercosis | 369·6 (260·6 to 489·8) | 303·6 (211·4 to 410·9) | −17·9 (−22·7 to −13·5)* | 5·9 (4·2 to 7·8) | 4·1 (2·9 to 5·5) | −30·4 (−34·3 to −26·5)* | |||
| Cystic echinococcosis | 174·1 (141·3 to 212·4) | 172·6 (132·1 to 220·6) | −0·8 (−7·4 to 4·5) | 2·8 (2·2 to 3·4) | 2·4 (1·8 to 3·0) | −14·7 (−20·2 to −10·2)* | |||
| Lymphatic filariasis | 2476·6 (1272·2 to 4008·8) | 2075·0 (1120·5 to 3311·5) | −16·2 (−32·1 to −3·8)* | 38·9 (20·0 to 63·1) | 28·1 (15·2 to 44·9) | −27·7 (−41·5 to −17·0)* | |||
| Onchocerciasis | 1441·6 (835·2 to 2288·7) | 1135·7 (545·8 to 2005·7) | −21·2 (−38·6 to −4·8)* | 22·5 (13·2 to 35·5) | 15·5 (7·5 to 27·3) | −31·2 (−46·8 to −16·0)* | |||
| Trachoma | 282·6 (194·3 to 396·1) | 279·2 (192·5 to 396·2) | −1·2 (−5·6 to 3·0) | 5·5 (3·8 to 7·7) | 4·2 (2·9 to 5·9) | −23·9 (−27·6 to −20·3)* | |||
| Dengue | 1132·8 (795·9 to 1616·2) | 1892·2 (1266·7 to 2925·2) | 67·0 (16·8 to 166·1)* | 16·6 (11·7 to 23·8) | 25·5 (17·1 to 39·5) | 53·5 (7·3 to 144·1)* | |||
| Yellow fever | 400·8 (83·3 to 1083·2) | 329·8 (66·9 to 898·1) | −17·7 (−34·1 to 1·7) | 5·8 (1·2 to 15·6) | 4·4 (0·9 to 12·1) | −23·0 (−38·2 to −4·9)* | |||
| Rabies | 1760·6 (1525·6 to 2019·8) | 931·6 (779·2 to 1120·9) | −47·1 (−54·2 to −39·3)* | 26·4 (23·0 to 30·2) | 12·6 (10·6 to 15·2) | −52·1 (−58·6 to −45·2)* | |||
| Intestinal nematode infections | 4404·5 (2719·6 to 6783·4) | 3378·3 (2046·2 to 5294·5) | −23·3 (−27·4 to −18·2)* | 65·8 (40·6 to 101·4) | 45·6 (27·6 to 71·4) | −30·7 (−34·5 to −26·1)* | |||
| Ascariasis | 1693·0 (1061·5 to 2610·7) | 1075·4 (685·1 to 1660·9) | −36·5 (−43·1 to −29·5)* | 25·2 (15·8 to 39·0) | 14·5 (9·2 to 22·4) | −42·5 (−48·6 to −36·2)* | |||
| Trichuriasis | 653·1 (357·9 to 1076·3) | 544·1 (289·3 to 946·1) | −16·7 (−30·6 to 3·7) | 9·8 (5·4 to 16·1) | 7·3 (3·9 to 12·8) | −24·9 (−37·5 to −6·7)* | |||
| Hookworm disease | 2058·4 (1275·6 to 3171·3) | 1758·8 (1085·8 to 2755·1) | −14·6 (−19·9 to −9·4)* | 30·8 (19·0 to 47·4) | 23·7 (14·7 to 37·1) | −22·9 (−27·7 to −18·1)* | |||
| Food-borne trematodiases | 1625·6 (793·1 to 3058·3) | 1686·5 (855·0 to 3072·8) | 3·7 (−0·5 to 10·1) | 25·1 (12·3 to 47·0) | 22·6 (11·5 to 41·0) | −10·0 (−13·5 to −5·2)* | |||
| Leprosy | 30·8 (20·6 to 43·0) | 31·0 (20·8 to 43·6) | 0·6 (−1·5 to 2·9) | 0·5 (0·4 to 0·8) | 0·4 (0·3 to 0·6) | −19·2 (−20·8 to −17·4)* | |||
| Ebola virus disease | 0·8 (0·7 to 1·0) | 295·4 (238·3 to 353·8) | 36 024·8 (36 010·3 to 36 054·6)* | 0·0 (0·0 to 0·0) | 3·9 (3·2 to 4·7) | 31 654·0 (31 640·5 to 31 681·3)* | |||
| Other neglected tropical diseases | 6213·6 (3655·0 to 11309·8) | 6461·0 (3516·3 to 13769·5) | 4·0 (−18·2 to 40·2) | 91·8 (53·8 to 167·4) | 87·6 (47·7 to 187·2) | −4·6 (−24·9 to 28·6) | |||
| Maternal disorders | 20 797·1 (19 462·4 to 22 290·3) | 16 282·0 (14 542·5 to 18 451·2) | −21·7 (−30·1 to −11·7)* | 299·0 (279·8 to 320·7) | 212·6 (189·9 to 240·9) | −28·9 (−36·5 to −19·8)* | |||
| Maternal haemorrhage | 5614·4 (4 902·4 to 6 402·8) | 4645·8 (3 769·9 to 5 636·8) | −17·3 (−28·9 to −4·6)* | 81·1 (70·8 to 92·3) | 60·7 (49·3 to 73·6) | −25·1 (−35·6 to −13·5)* | |||
| Maternal sepsis and other maternal infections | 1443·1 (1195·4 to 1742·2) | 1050·0 (792·7 to 1382·8) | −27·2 (−41·1 to −10·8)* | 20·8 (17·3 to 25·1) | 13·7 (10·4 to 18·0) | −34·1 (−46·8 to −19·0)* | |||
| Maternal hypertensive disorders | 3939·7 (3391·5 to 4579·2) | 2938·0 (2318·0 to 3698·5) | −25·4 (−35·9 to −13·2)* | 56·1 (48·3 to 65·2) | 38·3 (30·2 to 48·2) | −31·7 (−41·2 to −20·7)* | |||
| Maternal obstructed labour and uterine rupture | 1905·3 (1592·5 to 2242·8) | 1627·1 (1257·6 to 2025·1) | −14·6 (−25·4 to −2·4)* | 27·7 (23·2 to 32·5) | 21·2 (16·4 to 26·4) | −23·2 (−32·9 to −12·2)* | |||
| Maternal abortion miscarriage and ectopic pregnancy | 2366·6 (1992·0 to 2830·9) | 1809·7 (1416·9 to 2283·6) | −23·5 (−34·2 to −12·1)* | 34·0 (28·7 to 40·8) | 23·6 (18·5 to 29·8) | −30·5 (−40·1 to −20·1)* | |||
| Indirect maternal deaths | 2192·6 (1803·5 to 2621·7) | 1744·2 (1299·7 to 2286·8) | −20·4 (−33·2 to −3·4)* | 31·4 (25·9 to 37·5) | 22·7 (17·0 to 29·8) | −27·6 (−39·0 to −11·9)* | |||
| Late maternal deaths | 449·8 (295·7 to 652·2) | 377·7 (244·8 to 562·2) | −16·0 (−26·8 to −2·6)* | 6·5 (4·2 to 9·4) | 4·9 (3·2 to 7·3) | −23·6 (−33·7 to −11·4)* | |||
| Maternal deaths aggravated by HIV/AIDS | 149·9 (96·3 to 204·8) | 122·1 (73·3 to 176·5) | −18·6 (−35·2 to 4·2) | 2·2 (1·4 to 3·0) | 1·6 (1·0 to 2·3) | −27·1 (−42·1 to −6·8)* | |||
| Other maternal disorders | 2735·8 (2324·0 to 3245·0) | 1967·5 (1578·3 to 2434·9) | −28·1 (−36·5 to −18·1)* | 39·3 (33·4 to 46·6) | 25·7 (20·6 to 31·7) | −34·7 (−42·4 to −26·1)* | |||
| Neonatal disorders | 239 098·4 (232 872·7 to 246 048·9) | 197 924·8 (191 388·9 to 204 751·8) | −17·2 (−19·2 to −15·4)* | 3370·5 (3282·2 to 3468·1) | 2638·3 (2551·0 to 2 729·5) | −21·7 (−23·6 to −20·0)* | |||
| Neonatal preterm birth complications | 99 050·0 (92 118·6 to 110 250·8) | 74 833·6 (68 500·3 to 83 015·4) | −24·4 (−29·6 to −19·2)* | 1396·6 (1298·8 to 1554·2) | 997·5 (913·1 to 1106·5) | −28·6 (−33·4 to −23·6)* | |||
| Neonatal encephalopathy due to birth asphyxia and trauma | 79 423·6 (72 215·4 to 87 185·6) | 67 856·5 (61 497·7 to 75 824·7) | −14·6 (−21·7 to −6·7)* | 1118·8 (1017·3 to 1228·6) | 904·4 (819·6 to 1010·5) | −19·2 (−26·0 to −11·7)* | |||
| Neonatal sepsis and other neonatal infections | 30 510·1 (21 830·7 to 40 329·6) | 30 454·5 (21 591·8 to 39 747·9) | −0·2 (−16·2 to 20·3) | 429·6 (307·4 to 567·7) | 406·0 (287·8 to 529·8) | −5·5 (−20·6 to 13·9) | |||
| Haemolytic disease and other neonatal jaundice | 6427·0 (4234·6 to 9708·3) | 4504·0 (3202·7 to 6420·6) | −29·9 (−44·1 to −13·6)* | 90·9 (60·0 to 137·0) | 60·1 (42·7 to 85·6) | −33·9 (−47·2 to −18·6)* | |||
| Other neonatal disorders | 23 687·6 (17 420·2 to 30 795·3) | 20 276·2 (15 531·0 to 25 385·9) | −14·4 (−32·8 to 7·1) | 334·6 (246·3 to 434·7) | 270·4 (207·1 to 338·5) | −19·2 (−36·6 to 1·1) | |||
| Nutritional deficiencies | 84 133·3 (65 215·4 to 108 480·6) | 76 517·1 (58 781·9 to 100 939·6) | −9·1 (−15·2 to −3·5)* | 1242·7 (964·9 to 1598·6) | 1034·4 (795·9 to 1 363·6) | −16·8 (−22·4 to −11·7)* | |||
| Protein-energy malnutrition | 26 655·2 (21 449·8 to 32 723·9) | 21 094·0 (16 844·2 to 26 299·5) | −20·9 (−34·5 to −4·8)* | 395·1 (319·4 to 484·0) | 286·5 (228·9 to 356·6) | −27·5 (−39·8 to −13·0)* | |||
| Iodine deficiency | 2320·5 (1500·7 to 3422·1) | 2476·4 (1592·8 to 3662·1) | 6·7 (3·4 to 9·9)* | 35·3 (22·8 to 52·1) | 33·4 (21·5 to 49·4) | −5·2 (−8·4 to −2·4)* | |||
| Vitamin A deficiency | 209·5 (130·8 to 309·2) | 232·4 (143·4 to 346·3) | 10·9 (7·5 to 14·6)* | 3·1 (2·0 to 4·6) | 3·1 (1·9 to 4·7) | 0·2 (−2·7 to 3·3) | |||
| Iron-deficiency anaemia | 52 951·3 (36 342·0 to 74 873·5) | 51 217·1 (35 014·4 to 72 661·0) | −3·3 (−4·8 to −1·8)* | 778·6 (534·8 to 1 099·4) | 690·8 (472·4 to 979·6) | −11·3 (−12·7 to −10·0)* | |||
| Other nutritional deficiencies | 1996·8 (1378·4 to 2848·4) | 1497·2 (1135·7 to 1983·7) | −25·0 (−43·3 to −9·4)* | 30·5 (21·2 to 43·5) | 20·5 (15·7 to 27·1) | −32·7 (−48·9 to −19·0)* | |||
| Other communicable, maternal, neonatal, and nutritional diseases | 25 182·6 (20 002·2 to 31 397·3) | 21 792·2 (17 474·0 to 26 922·3) | −13·5 (−18·6 to −7·8)* | 373·1 (298·4 to 462·5) | 293·8 (235·7 to 362·6) | −21·2 (−25·9 to −16·1)* | |||
| Sexually transmitted diseases excluding HIV | 12 378·7 (7 831·6 to 18 396·6) | 10 330·9 (6 583·0 to 15 315·1) | −16·5 (−24·2 to −8·6)* | 178·7 (113·6 to 264·7) | 138·1 (87·9 to 205·0) | −22·7 (−29·6 to −15·5)* | |||
| Syphilis | 11 190·5 (6 607·1 to 17 280·8) | 8957·1 (5273·2 to 13969·7) | −20·0 (−28·4 to −11·8)* | 160·9 (95·4 to 247·9) | 120·1 (70·8 to 187·2) | −25·4 (−33·3 to −17·7)* | |||
| Chlamydial infection | 337·0 (194·2 to 537·7) | 369·8 (214·0 to 595·4) | 9·7 (6·5 to 13·0)* | 4·9 (2·8 to 7·8) | 4·8 (2·8 to 7·7) | −2·3 (−5·0 to 0·5) | |||
| Gonococcal infection | 382·8 (238·6 to 573·0) | 469·8 (283·4 to 716·8) | 22·7 (15·9 to 28·1)* | 5·6 (3·5 to 8·4) | 6·1 (3·7 to 9·3) | 8·8 (2·8 to 13·8)* | |||
| Trichomoniasis | 167·4 (67·1 to 354·8) | 194·3 (77·8 to 412·1) | 16·1 (15·0 to 17·2)* | 2·5 (1·0 to 5·4) | 2·6 (1·0 to 5·4) | 1·0 (0·3 to 1·8)* | |||
| Genital herpes | 197·8 (61·5 to 468·3) | 236·4 (74·3 to 555·8) | 19·5 (17·4 to 23·0)* | 3·2 (1·0 to 7·6) | 3·2 (1·0 to 7·5) | 0·7 (−1·5 to 5·2) | |||
| Other sexually transmitted diseases | 103·2 (74·9 to 139·2) | 103·5 (74·3 to 141·2) | 0·3 (−3·1 to 3·2) | 1·6 (1·1 to 2·1) | 1·4 (1·0 to 1·9) | −13·2 (−16·1 to −10·6)* | |||
| Hepatitis | 6042·4 (5738·7 to 6344·8) | 4925·3 (4634·8 to 5229·3) | −18·5 (−22·7 to −14·1)* | 93·0 (88·6 to 97·5) | 66·7 (62·8 to 70·8) | −28·3 (−31·9 to −24·6)* | |||
| Acute hepatitis A | 1486·6 (1058·5 to 1896·9) | 1030·3 (714·9 to 1335·9) | −30·7 (−39·7 to −20·8)* | 21·5 (15·2 to 27·5) | 13·8 (9·6 to 17·9) | −35·6 (−43·9 to −26·4)* | |||
| Hepatitis B | 2693·5 (2298·5 to 3080·0) | 2449·1 (2083·5 to 2799·2) | −9·1 (−15·4 to −2·0)* | 44·0 (37·8 to 50·0) | 33·4 (28·5 to 38·1) | −24·1 (−29·2 to −18·6)* | |||
| Hepatitis C | 98·4 (26·2 to 220·4) | 89·1 (25·5 to 201·9) | −9·5 (−23·3 to 7·6) | 1·6 (0·4 to 3·7) | 1·2 (0·3 to 2·8) | −25·9 (−37·5 to −11·0)* | |||
| Acute hepatitis E | 1763·9 (1304·1 to 2265·3) | 1356·8 (972·0 to 1794·4) | −23·1 (−31·6 to −14·0)* | 25·9 (19·0 to 33·7) | 18·3 (13·1 to 24·2) | −29·6 (−37·1 to −21·6)* | |||
| Other infectious diseases | 6761·5 (4784·8 to 8106·7) | 6536·0 (4527·7 to 7935·6) | −3·3 (−13·9 to 9·2) | 101·3 (72·0 to 120·9) | 89·0 (61·6 to 107·8) | −12·2 (−21·6 to −1·0)* | |||
| Non-communicable diseases | 1 322 207·9 (1 181 179·7 to 1 471 448·8) | 1 473 508·2 (1 309 803·2 to 1 650 147·4) | 11·4 (9·7 to 13·0)* | 23 220·2 (20 898·5 to 25 689·0) | 21 062·4 (18 790·6 to 23 518·0) | −9·3 (−10·9 to −7·9)* | |||
| Neoplasms | 187 562·1 (183 699·7 to 191 539·2) | 209 359·2 (204 155·5 to 214 470·1) | 11·6 (9·3 to 14·2)* | 3424·3 (3356·2 to 3494·4) | 3024·4 (2949·8 to 3098·9) | −11·7 (−13·4 to −9·7)* | |||
| Lip and oral cavity cancer | 2954·1 (2866·9 to 3050·0) | 3780·1 (3645·7 to 3928·9) | 28·0 (23·9 to 32·6)* | 53·7 (52·1 to 55·4) | 53·7 (51·8 to 55·8) | 0·1 (−3·1 to 3·7) | |||
| Nasopharynx cancer | 1805·8 (1477·1 to 1912·4) | 1911·7 (1562·1 to 2040·2) | 5·9 (−2·2 to 12·4) | 30·9 (25·4 to 32·7) | 26·5 (21·6 to 28·2) | −14·3 (−20·6 to −9·0)* | |||
| Other pharynx cancer | 1419·9 (1374·7 to 1468·8) | 1715·7 (1635·4 to 1795·0) | 20·8 (15·2 to 26·3)* | 25·9 (25·1 to 26·8) | 24·3 (23·2 to 25·4) | −6·3 (−10·7 to −2·1)* | |||
| Oesophageal cancer | 10 665·4 (10 313·5 to 11 043·9) | 9 854·4 (9 465·3 to 10 270·8) | −7·6 (−12·4 to −2·1)* | 201·0 (194·5 to 207·8) | 143·6 (137·9 to 149·5) | −28·6 (−32·2 to −24·4)* | |||
| Stomach cancer | 18 665·9 (18 186·3 to 19 175·5) | 17 439·6 (16 876·7 to 18 034·6) | −6·6 (−9·7 to −3·3)* | 350·6 (341·9 to 360·0) | 255·9 (247·9 to 264·5) | −27·0 (−29·4 to −24·5)* | |||
| Colon and rectum cancer | 14 409·5 (14 108·0 to 14 779·0) | 17 026·6 (16 586·7 to 17 504·7) | 18·2 (15·7 to 20·9)* | 274·0 (268·2 to 280·8) | 251·3 (244·9 to 258·4) | −8·3 (−10·2 to −6·2)* | |||
| Liver cancer | 19 643·6 (16 871·4 to 20 641·2) | 20 578·0 (18 937·8 to 21 915·3) | 4·8 (−1·4 to 15·5) | 350·9 (302·8 to 368·5) | 292·1 (269·1 to 311·0) | −16·8 (−21·4 to −8·7)* | |||
| Liver cancer due to hepatitis B | 8420·5 (7092·2 to 9020·2) | 8029·5 (7279·6 to 8795·5) | −4·6 (−11·2 to 8·2) | 143·4 (121·3 to 153·7) | 110·6 (100·4 to 121·2) | −22·9 (−27·9 to −12·9)* | |||
| Liver cancer due to hepatitis C | 2897·4 (2607·7 to 3109·1) | 3324·0 (3012·2 to 3573·6) | 14·7 (10·3 to 20·2)* | 55·5 (50·1 to 59·5) | 49·3 (44·9 to 52·9) | −11·2 (−14·4 to −7·1)* | |||
| Liver cancer due to alcohol use | 4786·9 (4075·0 to 5168·7) | 5888·5 (5368·4 to 6441·0) | 23·0 (14·8 to 36·1)* | 89·2 (76·2 to 96·3) | 84·8 (77·5 to 92·7) | −4·9 (−11·1 to 4·8) | |||
| Liver cancer due to other causes | 3538·8 (3022·8 to 3829·6) | 3336·0 (3019·1 to 3637·7) | −5·7 (−11·2 to 3·8) | 62·9 (54·1 to 68·1) | 47·4 (42·9 to 51·6) | −24·6 (−28·9 to −17·5)* | |||
| Gallbladder and biliary tract cancer | 2448·7 (2359·2 to 2524·3) | 2615·7 (2454·6 to 2740·8) | 6·8 (2·2 to 11·6)* | 47·3 (45·7 to 48·7) | 39·0 (36·7 to 40·9) | −17·5 (−21·0 to −13·8)* | |||
| Pancreatic cancer | 6528·1 (6433·9 to 6630·7) | 8236·6 (8064·7 to 8420·0) | 26·2 (23·3 to 29·0)* | 125·2 (123·4 to 127·0) | 121·8 (119·3 to 124·4) | −2·7 (−4·8 to −0·6)* | |||
| Larynx cancer | 2364·1 (2290·8 to 2443·5) | 2608·5 (2518·3 to 2705·0) | 10·3 (7·1 to 13·9)* | 44·0 (42·7 to 45·5) | 37·6 (36·3 to 39·0) | −14·5 (−17·0 to −11·8)* | |||
| Tracheal, bronchus, and lung cancer | 31 802·0 (31 117·2 to 32 516·2) | 36 419·5 (35 356·6 to 37 615·6) | 14·5 (11·0 to 19·1)* | 604·5 (591·8 to 617·4) | 535·9 (520·3 to 553·1) | −11·3 (−14·0 to −7·9)* | |||
| Malignant skin melanoma | 1304·0 (1086·8 to 1655·2) | 1596·3 (1293·4 to 1982·7) | 22·4 (15·6 to 27·5)* | 23·3 (19·4 to 29·6) | 22·8 (18·4 to 28·3) | −2·3 (−7·7 to 1·7) | |||
| Non-melanoma skin cancer | 794·3 (764·9 to 828·0) | 1088·8 (1028·3 to 1150·1) | 37·1 (32·0 to 41·9)* | 15·2 (14·7 to 15·9) | 16·3 (15·4 to 17·2) | 6·8 (2·8 to 10·6)* | |||
| Non-melanoma skin cancer (squamous-cell carcinoma) | 789·6 (761·2 to 822·3) | 1082·9 (1025·0 to 1142·0) | 37·1 (32·0 to 42·0)* | 15·1 (14·6 to 15·8) | 16·2 (15·3 to 17·1) | 6·9 (2·9 to 10·6)* | |||
| Non-melanoma skin cancer (basal-cell carcinoma) | 4·7 (2·2 to 8·7) | 6·0 (2·8 to 11·1) | 26·9 (23·4 to 30·2)* | 0·1 (0·0 to 0·2) | 0·1 (0·0 to 0·2) | −3·8 (−6·5 to −1·2)* | |||
| Breast cancer | 12 939·2 (12 181·7 to 13 828·7) | 15 410·6 (14 415·5 to 16 217·8) | 19·1 (11·6 to 25·8)* | 231·4 (218·3 to 246·9) | 217·1 (203·2 to 228·7) | −6·2 (−11·9 to −1·1)* | |||
| Cervical cancer | 6819·2 (6393·4 to 7236·4) | 6963·0 (6526·2 to 7408·0) | 2·1 (−4·5 to 10·5) | 118·9 (111·8 to 126·1) | 96·7 (90·7 to 102·7) | −18·7 (−23·9 to −12·2)* | |||
| Uterine cancer | 2077·7 (1963·6 to 2201·8) | 2230·7 (2098·3 to 2386·9) | 7·4 (0·3 to 15·8)* | 38·7 (36·6 to 40·9) | 32·2 (30·3 to 34·5) | −16·6 (−22·0 to −10·1)* | |||
| Ovarian cancer | 3496·3 (3401·0 to 3660·5) | 4135·9 (3992·4 to 4298·0) | 18·3 (13·4 to 23·1)* | 63·2 (61·5 to 66·0) | 58·6 (56·6 to 60·8) | −7·3 (−11·0 to −3·8)* | |||
| Prostate cancer | 4793·4 (3992·1 to 6079·2) | 6281·2 (5233·9 to 7904·2) | 31·0 (26·9 to 35·2)* | 100·0 (83·5 to 126·8) | 99·6 (83·0 to 125·7) | −0·4 (−3·5 to 2·6) | |||
| Testicular cancer | 411·3 (390·2 to 435·8) | 442·6 (413·1 to 473·3) | 7·6 (0·3 to 13·6)* | 6·3 (6·0 to 6·7) | 5·9 (5·5 to 6·3) | −6·4 (−12·6 to −1·2)* | |||
| Kidney cancer | 2649·3 (2539·2 to 2779·3) | 3340·3 (3189·6 to 3513·2) | 26·1 (21·2 to 30·6)* | 48·5 (46·8 to 50·6) | 48·4 (46·2 to 50·8) | −0·3 (−3·8 to 3·0) | |||
| Bladder cancer | 2832·7 (2754·6 to 2908·1) | 3368·8 (3251·3 to 3496·5) | 18·9 (15·4 to 22·4)* | 56·3 (54·8 to 57·8) | 51·3 (49·5 to 53·2) | −8·8 (−11·5 to −6·2)* | |||
| Brain and nervous system cancer | 6738·3 (6079·6 to 7270·6) | 7624·4 (6975·3 to 8218·8) | 13·2 (5·0 to 21·0)* | 111·4 (100·8 to 119·7) | 105·6 (96·7 to 113·7) | −5·2 (−11·7 to 1·2) | |||
| Thyroid cancer | 649·6 (605·3 to 707·6) | 846·3 (754·1 to 929·0) | 30·3 (19·2 to 37·4)* | 12·1 (11·3 to 13·2) | 12·4 (11·1 to 13·6) | 2·2 (−6·2 to 7·8) | |||
| Mesothelioma | 544·9 (529·2 to 560·6) | 701·9 (678·8 to 722·2) | 28·8 (24·3 to 33·3)* | 10·1 (9·8 to 10·3) | 10·3 (9·9 to 10·5) | 2·0 (−1·5 to 5·4) | |||
| Hodgkin's lymphoma | 949·3 (837·3 to 1120·9) | 845·6 (758·4 to 1031·7) | −10·9 (−14·9 to −6·7)* | 15·5 (13·7 to 18·3) | 11·6 (10·5 to 14·2) | −24·7 (−28·2 to −21·1)* | |||
| Non-Hodgkin lymphoma | 5063·1 (4581·8 to 5581·3) | 6283·8 (5449·8 to 6632·3) | 24·1 (11·5 to 31·7)* | 88·3 (79·7 to 96·6) | 89·5 (77·5 to 94·3) | 1·3 (−8·5 to 7·0) | |||
| Multiple myeloma | 1694·3 (1646·6 to 1751·4) | 2182·4 (2096·5 to 2255·8) | 28·8 (23·8 to 33·2)* | 32·2 (31·2 to 33·2) | 32·1 (30·8 to 33·1) | −0·4 (−4·1 to 2·9) | |||
| Leukaemia | 11 272·2 (10 956·3 to 11 683·7) | 12 040·4 (11 609·8 to 12 499·3) | 6·8 (2·9 to 10·5)* | 181·6 (176·6 to 187·8) | 167·7 (161·8 to 173·9) | −7·6 (−10·8 to −4·6)* | |||
| Acute lymphoid leukaemia | 4857·0 (4505·3 to 5452·8) | 5057·8 (4658·4 to 5507·7) | 4·1 (−1·7 to 9·9) | 73·6 (68·3 to 82·4) | 69·1 (63·6 to 75·2) | −6·1 (−11·3 to −1·0)* | |||
| Chronic lymphoid leukaemia | 1183·2 (1107·9 to 1256·6) | 1268·6 (1194·2 to 1349·3) | 7·2 (1·8 to 12·8)* | 21·8 (20·5 to 23·1) | 18·7 (17·7 to 19·9) | −14·1 (−18·3 to −10·0)* | |||
| Acute myeloid leukaemia | 4199·7 (3770·1 to 4553·5) | 4769·0 (4345·7 to 5193·7) | 13·6 (8·2 to 18·5)* | 68·5 (62·1 to 74·0) | 66·6 (60·8 to 72·5) | −2·8 (−7·0 to 1·1) | |||
| Chronic myeloid leukaemia | 1032·3 (957·8 to 1131·8) | 945·1 (885·8 to 1032·9) | −8·5 (−12·3 to −3·8)* | 17·7 (16·5 to 19·3) | 13·3 (12·5 to 14·5) | −24·8 (−27·8 to −21·2)* | |||
| Other neoplasms | 9825·9 (9023·1 to 10 351·7) | 11 789·9 (10 528·0 to 12 616·2) | 20·0 (13·4 to 25·7)* | 163·3 (150·1 to 171·6) | 164·6 (146·8 to 175·8) | 0·8 (−4·5 to 5·5) | |||
| Cardiovascular diseases | 326 252·4 (318 365·8 to 334 285·8) | 347 528·9 (337 220·3 to 358 093·5) | 6·5 (4·1 to 8·7)* | 6231·9 (6086·8 to 6378·1) | 5179·7 (5026·3 to 5334·2) | −16·9 (−18·7 to −15·3)* | |||
| Rheumatic heart disease | 11 594·7 (10 668·9 to 12 707·4) | 10 513·2 (9 611·0 to 11 514·5) | −9·3 (−13·3 to −5·7)* | 193·6 (178·4 to 210·6) | 146·6 (134·2 to 160·1) | −24·3 (−27·5 to −21·3)* | |||
| Ischaemic heart disease | 147 780·0 (144 845·9 to 151 651·5) | 164 020·4 (159 621·3 to 169 088·2) | 11·0 (8·3 to 13·3)* | 2860·0 (2805·1 to 2927·3) | 2452·6 (2388·9 to 2526·8) | −14·2 (−16·2 to −12·5)* | |||
| Cerebrovascular disease | 118 566·2 (115 776·1 to 121 419·2) | 118 626·7 (114 862·4 to 122 627·0) | 0·1 (−2·5 to 2·7) | 2283·2 (2230·3 to 2335·8) | 1776·6 (1721·1 to 1834·8) | −22·2 (−24·1 to −20·1)* | |||
| Ischaemic stroke | 44 104·6 (42 363·3 to 45 822·3) | 45 208·5 (43 150·2 to 47 386·8) | 2·5 (−0·4 to 5·2) | 903·6 (869·6 to 936·9) | 706·2 (675·6 to 739·0) | −21·8 (−24·0 to −19·8)* | |||
| Haemorrhagic stroke | 74 461·5 (72 176·9 to 76 874·3) | 73 418·2 (70 737·2 to 76 596·4) | −1·4 (−4·6 to 2·1) | 1379·6 (1337·6 to 1423·6) | 1070·4 (1032·1 to 1116·3) | −22·4 (−25·0 to −19·6)* | |||
| Hypertensive heart disease | 14 852·4 (13 919·4 to 16 052·6) | 17 484·6 (16 286·9 to 18 593·6) | 17·7 (11·6 to 22·9)* | 286·5 (268·8 to 309·8) | 262·2 (243·2 to 279·1) | −8·5 (−13·4 to −4·5)* | |||
| Cardiomyopathy and myocarditis | 9619·8 (9134·6 to 9993·7) | 9220·3 (8765·6 to 9706·0) | −4·2 (−8·3 to −0·1)* | 163·4 (155·8 to 169·5) | 130·0 (123·7 to 136·7) | −20·5 (−23·7 to −17·2)* | |||
| Atrial fibrillation and flutter | 3463·2 (2764·5 to 4281·3) | 4433·7 (3541·7 to 5489·1) | 28·0 (26·6 to 29·3)* | 73·8 (59·3 to 90·5) | 70·6 (56·5 to 86·9) | −4·2 (−5·3 to −3·3)* | |||
| Aortic aneurysm | 2468·0 (2403·2 to 2547·3) | 2930·2 (2846·0 to 3007·0) | 18·7 (12·9 to 22·6)* | 47·6 (46·4 to 49·1) | 43·8 (42·6 to 45·0) | −7·9 (−12·3 to −5·0)* | |||
| Peripheral vascular disease | 913·0 (686·4 to 1279·3) | 1198·8 (898·0 to 1682·6) | 31·3 (27·7 to 35·2)* | 19·3 (14·5 to 26·9) | 19·1 (14·3 to 26·8) | −1·1 (−3·9 to 1·7) | |||
| Endocarditis | 1962·3 (1616·0 to 2190·5) | 2210·3 (1838·9 to 2421·3) | 12·6 (6·3 to 18·8)* | 33·0 (27·7 to 36·7) | 31·2 (26·1 to 34·2) | −5·5 (−10·2 to −0·9)* | |||
| Other cardiovascular and circulatory diseases | 15 032·7 (13 427·8 to 16 820·7) | 16 890·7 (14 824·7 to 19 104·2) | 12·4 (8·4 to 15·6)* | 271·6 (243·4 to 303·7) | 247·0 (217·2 to 279·2) | −9·0 (−12·1 to −6·5)* | |||
| Chronic respiratory diseases | 97 356·3 (90 607·8 to 104 559·9) | 97 451·8 (89 829·7 to 105 527·6) | 0·1 (−2·4 to 2·6) | 1802·0 (1694·4 to 1915·3) | 1443·4 (1336·9 to 1556·8) | −19·9 (−22·2 to −17·8)* | |||
| Chronic obstructive pulmonary disease | 63 773·8 (60 981·4 to 66 186·6) | 63 850·4 (61 215·3 to 66 288·6) | 0·1 (−3·1 to 3·8) | 1246·9 (1195·2 to 1291·9) | 971·1 (932·7 to 1 007·6) | −22·1 (−24·6 to −19·2)* | |||
| Pneumoconiosis | 976·7 (816·2 to 1 168·6) | 1 099·6 (902·7 to 1 314·7) | 12·6 (6·9 to 18·9)* | 17·8 (15·0 to 21·1) | 16·0 (13·2 to 19·1) | −9·9 (−14·8 to −4·7)* | |||
| Silicosis | 271·5 (240·1 to 308·1) | 270·2 (235·8 to 310·1) | −0·5 (−10·1 to 11·5) | 5·0 (4·5 to 5·7) | 4·0 (3·5 to 4·5) | −21·3 (−28·7 to −12·0)* | |||
| Asbestosis | 76·3 (63·0 to 87·9) | 92·0 (75·3 to 107·2) | 20·5 (13·7 to 27·8)* | 1·4 (1·2 to 1·6) | 1·4 (1·1 to 1·6) | −3·8 (−8·9 to 1·7) | |||
| Coal worker's pneumoconiosis | 59·7 (52·8 to 67·4) | 57·5 (49·0 to 67·2) | −3·6 (−17·4 to 9·4) | 1·2 (1·0 to 1·3) | 0·9 (0·7 to 1·0) | −25·1 (−35·6 to −15·1)* | |||
| Other pneumoconiosis | 569·3 (440·2 to 715·7) | 680·0 (526·2 to 855·9) | 19·5 (13·4 to 25·9)* | 10·2 (8·0 to 12·7) | 9·8 (7·6 to 12·3) | −3·4 (−9·0 to 2·3) | |||
| Asthma | 26 859·7 (21 268·1 to 33 122·5) | 26 168·8 (20 501·4 to 32 583·0) | −2·6 (−9·2 to 4·2) | 439·8 (351·4 to 537·5) | 365·6 (287·5 to 453·5) | −16·9 (−23·5 to −10·3)* | |||
| Interstitial lung disease and pulmonary sarcoidosis | 1672·3 (1351·2 to 1954·1) | 2352·6 (1933·8 to 2618·7) | 40·7 (29·2 to 48·8)* | 32·0 (25·7 to 37·2) | 35·4 (28·9 to 39·3) | 10·3 (1·5 to 16·7)* | |||
| Other chronic respiratory diseases | 4073·7 (3295·2 to 4805·9) | 3980·4 (3225·6 to 4569·7) | −2·3 (−11·0 to 7·3) | 65·5 (53·3 to 76·6) | 55·4 (44·9 to 63·5) | −15·3 (−22·4 to −7·5)* | |||
| Cirrhosis and other chronic liver diseases | 37 101·5 (35 722·1 to 39 385·8) | 38 973·3 (37 202·0 to 41 702·9) | 5·0 (1·6 to 8·7)* | 632·5 (609·4 to 669·2) | 539·6 (515·4 to 576·8) | −14·7 (−17·4 to −11·8)* | |||
| Cirrhosis and other chronic liver diseases due to hepatitis B | 10 297·6 (9 495·9 to 11 233·5) | 10 754·7 (9 876·8 to 11 957·6) | 4·4 (0·2 to 8·6)* | 178·0 (164·1 to 194·8) | 149·5 (137·3 to 165·9) | −16·0 (−19·2 to −12·7)* | |||
| Cirrhosis and other chronic liver diseases due to hepatitis C | 8408·4 (7768·6 to 9069·5) | 9161·7 (8443·3 to 9968·2) | 9·0 (5·7 to 12·3)* | 146·5 (135·6 to 157·9) | 127·4 (117·6 to 138·4) | −13·0 (−15·6 to −10·4)* | |||
| Cirrhosis and other chronic liver diseases due to alcohol use | 10 093·5 (9 424·0 to 10 841·4) | 10 997·4 (10 197·4 to 11 875·1) | 9·0 (5·0 to 13·7)* | 171·9 (160·5 to 184·3) | 150·7 (139·7 to 162·6) | −12·3 (−15·5 to −8·6)* | |||
| Cirrhosis and other chronic liver diseases due to other causes | 8302·1 (7741·5 to 9165·9) | 8059·5 (7452·2 to 8977·7) | −2·9 (−6·5 to 1·3) | 136·1 (126·8 to 149·9) | 112·0 (103·6 to 124·7) | −17·7 (−20·6 to −14·3)* | |||
| Digestive diseases | 41 351·8 (37 701·8 to 45 778·3) | 42 189·1 (38 101·1 to 47 087·5) | 2·0 (−2·7 to 6·2) | 716·3 (653·0 to 793·4) | 600·3 (542·1 to 670·1) | −16·2 (−19·7 to −12·9)* | |||
| Peptic ulcer disease | 10 164·0 (9220·6 to 11 279·2) | 8894·4 (7950·0 to 10 039·2) | −12·5 (−17·7 to −5·9)* | 180·8 (163·9 to 201·3) | 128·5 (114·6 to 145·3) | −28·9 (−33·2 to −23·6)* | |||
| Gastritis and duodenitis | 5757·0 (4331·9 to 7638·9) | 6145·5 (4517·3 to 8251·9) | 6·7 (2·5 to 11·1)* | 100·9 (76·0 to 134·0) | 87·8 (64·6 to 118·0) | −13·1 (−16·4 to −9·7)* | |||
| Appendicitis | 2197·3 (1823·7 to 2661·6) | 2015·9 (1631·6 to 2381·2) | −8·3 (−21·5 to 6·4) | 34·4 (28·7 to 41·2) | 27·6 (22·4 to 32·6) | −19·6 (−30·7 to −6·8)* | |||
| Paralytic ileus and intestinal obstruction | 6957·0 (6123·4 to 8236·1) | 7135·5 (6464·3 to 8502·6) | 2·6 (−5·5 to 11·2) | 117·3 (104·1 to 138·5) | 100·7 (91·4 to 119·7) | −14·2 (−20·1 to −7·5)* | |||
| Inguinal femoral and abdominal hernia | 1689·6 (1147·1 to 1996·2) | 1645·7 (1089·7 to 1969·1) | −2·6 (−9·8 to 7·0) | 29·2 (20·1 to 34·2) | 23·4 (15·6 to 27·9) | −19·7 (−26·1 to −11·8)* | |||
| Inflammatory bowel disease | 3222·5 (2514·5 to 4041·9) | 3588·0 (2797·3 to 4483·0) | 11·3 (5·1 to 15·4)* | 53·8 (42·3 to 67·1) | 49·8 (39·0 to 62·0) | −7·5 (−12·2 to −4·3)* | |||
| Vascular intestinal disorders | 1475·6 (1358·6 to 1619·3) | 1741·6 (1607·3 to 1903·4) | 18·0 (12·8 to 23·7)* | 28·8 (26·6 to 31·5) | 26·5 (24·5 to 28·8) | −8·2 (−12·2 to −3·9)* | |||
| Gallbladder and biliary diseases | 2706·6 (2459·3 to 2994·3) | 2878·7 (2597·4 to 3161·8) | 6·4 (−0·2 to 11·9) | 48·3 (44·1 to 53·0) | 41·6 (37·6 to 45·6) | −13·8 (−18·7 to −9·6)* | |||
| Pancreatitis | 3765·2 (3501·1 to 4071·3) | 4373·2 (4000·1 to 4766·0) | 16·1 (9·2 to 23·2)* | 62·8 (58·5 to 67·8) | 60·2 (55·1 to 65·5) | −4·1 (−9·6 to 1·6) | |||
| Other digestive diseases | 3417·0 (2883·7 to 4228·0) | 3770·5 (3180·0 to 4438·8) | 10·3 (−0·1 to 22·2) | 60·0 (51·0 to 73·9) | 54·2 (45·9 to 63·7) | −9·7 (−18·0 to −0·4)* | |||
| Neurological disorders | 74 456·9 (58 081·0 to 93 693·7) | 87 082·1 (67 962·4 to 109 039·4) | 17·0 (15·5 to 18·5)* | 1291·0 (1025·5 to 1596·9) | 1252·4 (987·9 to 1556·6) | −3·0 (−4·2 to −2·0)* | |||
| Alzheimer's disease and other dementias | 17 905·9 (15 147·4 to 20 849·2) | 23 779·2 (20 118·0 to 27 886·0) | 32·8 (31·2 to 34·4)* | 409·6 (348·0 to 479·2) | 395·6 (333·5 to 463·8) | −3·4 (−4·4 to −2·5)* | |||
| Parkinson's disease | 1548·9 (1381·7 to 1747·5) | 2059·3 (1831·8 to 2320·9) | 32·9 (29·7 to 35·7)* | 32·8 (29·4 to 36·8) | 33·1 (29·5 to 37·2) | 1·1 (−1·3 to 3·1) | |||
| Epilepsy | 12 892·1 (10 694·5 to 15 020·3) | 12 417·9 (10 438·3 to 14 478·8) | −3·7 (−8·6 to 1·3) | 194·1 (160·8 to 226·1) | 167·6 (140·8 to 195·3) | −13·7 (−17·9 to −9·3)* | |||
| Multiple sclerosis | 1076·7 (913·9 to 1248·8) | 1233·7 (1033·4 to 1436·9) | 14·6 (9·9 to 18·4)* | 18·1 (15·4 to 21·0) | 16·9 (14·2 to 19·7) | −6·6 (−10·3 to −3·6)* | |||
| Motor neuron disease | 759·2 (728·7 to 806·3) | 910·0 (872·2 to 958·5) | 19·9 (13·6 to 23·2)* | 13·6 (13·1 to 14·4) | 13·1 (12·5 to 13·8) | −3·9 (−9·0 to −1·3)* | |||
| Migraine | 28 538·7 (17 584·9 to 42 479·8) | 32 898·8 (20 294·8 to 48 945·4) | 15·3 (14·0 to 16·6)* | 435·2 (268·4 to 647·8) | 438·7 (271·0 to 653·8) | 0·8 (−0·1 to 1·8) | |||
| Tension-type headache | 1961·3 (915·9 to 3647·4) | 2260·5 (1054·6 to 4193·3) | 15·3 (14·0 to 16·7)* | 30·0 (14·0 to 55·5) | 30·2 (14·1 to 56·0) | 0·6 (−0·1 to 1·3) | |||
| Medication overuse headache | 7705·4 (5100·2 to 10997·3) | 9164·7 (6089·3 to 13080·8) | 18·9 (15·4 to 22·8)* | 123·0 (82·3 to 175·3) | 123·7 (82·2 to 177·0) | 0·6 (−2·3 to 3·5) | |||
| Other neurological disorders | 2070·4 (1941·6 to 2302·3) | 2359·5 (2216·5 to 2565·4) | 14·0 (9·4 to 17·5)* | 34·6 (32·2 to 38·0) | 33·6 (31·3 to 36·4) | −3·1 (−6·4 to −0·4)* | |||
| Mental and substance use disorders | 141 375·1 (105 843·7 to 178 447·3) | 162 442·3 (121 032·0 to 205 579·7) | 14·9 (14·1 to 15·7)* | 2189·2 (1646·0 to 2762·8) | 2183·3 (1627·1 to 2766·3) | −0·3 (−1·0 to 0·3) | |||
| Schizophrenia | 13 185·0 (9 635·3 to 16 203·0) | 15 516·1 (11 279·2 to 19 137·0) | 17·7 (16·5 to 18·8)* | 210·4 (154·7 to 258·4) | 207·5 (151·1 to 255·5) | −1·4 (−2·4 to −0·5)* | |||
| Alcohol use disorders | 11 566·7 (9 617·6 to 13 834·9) | 11 194·3 (9 136·5 to 13 870·9) | −3·2 (−7·0 to 0·6) | 183·4 (153·5 to 218·3) | 149·4 (122·1 to 184·8) | −18·5 (−22·0 to −15·1)* | |||
| Drug use disorders | 13 671·4 (11 292·6 to 16 046·0) | 16 909·5 (14 037·6 to 19 871·6) | 23·7 (18·6 to 27·2)* | 207·2 (171·5 to 242·7) | 223·5 (185·8 to 262·2) | 7·9 (3·5 to 10·9)* | |||
| Opioid use disorders | 9864·0 (8127·4 to 11516·8) | 12 068·1 (9 878·0 to 14 145·1) | 22·3 (17·5 to 26·1)* | 150·2 (123·7 to 175·3) | 159·3 (130·7 to 186·6) | 6·0 (1·8 to 9·2)* | |||
| Cocaine use disorders | 729·3 (558·4 to 902·4) | 999·3 (773·5 to 1 233·9) | 37·0 (29·2 to 47·0)* | 11·3 (8·7 to 14·0) | 13·4 (10·4 to 16·6) | 18·7 (12·1 to 27·3)* | |||
| Amphetamine use disorders | 1001·3 (706·2 to 1348·3) | 1402·6 (1025·2 to 1846·9) | 40·1 (26·1 to 55·2)* | 14·6 (10·4 to 19·6) | 18·4 (13·5 to 24·2) | 25·8 (13·3 to 39·4)* | |||
| Cannabis use disorders | 548·1 (351·9 to 780·7) | 577·2 (371·8 to 817·6) | 5·3 (3·7 to 7·1)* | 7·9 (5·0 to 11·2) | 7·6 (4·9 to 10·7) | −3·7 (−5·0 to −2·3)* | |||
| Other drug use disorders | 1528·7 (1245·5 to 1861·2) | 1862·2 (1501·6 to 2274·2) | 21·8 (15·7 to 27·5)* | 23·1 (19·0 to 28·0) | 24·8 (20·0 to 30·2) | 7·1 (1·7 to 12·0)* | |||
| Depressive disorders | 45 916·0 (31 684·6 to 61 591·2) | 54 255·4 (37 513·6 to 72 968·9) | 18·2 (17·2 to 19·2)* | 726·9 (503·8 to 975·9) | 734·2 (508·2 to 986·9) | 1·0 (0·5 to 1·5)* | |||
| Major depressive disorder | 37 544·8 (24 983·0 to 51 134·6) | 44 224·4 (29 542·6 to 60 430·5) | 17·8 (16·6 to 19·0)* | 590·9 (395·0 to 804·5) | 597·2 (399·6 to 816·6) | 1·1 (0·5 to 1·7)* | |||
| Dysthymia | 8 371·3 (5 537·6 to 11 983·7) | 10 031·0 (6 604·4 to 14 289·3) | 19·8 (18·3 to 21·5)* | 136·1 (89·8 to 194·6) | 137·0 (90·0 to 195·3) | 0·7 (−0·2 to 1·6) | |||
| Bipolar disorder | 7838·8 (4787·8 to 11674·9) | 9004·7 (5501·3 to 13396·4) | 14·9 (13·9 to 15·9)* | 119·0 (72·8 to 176·9) | 119·6 (73·2 to 177·8) | 0·5 (0·0 to 0·9) | |||
| Anxiety disorders | 21 474·8 (14 666·7 to 29 339·6) | 24 643·0 (16 799·8 to 33 714·1) | 14·8 (12·8 to 16·6)* | 329·2 (225·4 to 448·4) | 332·4 (227·0 to 453·8) | 1·0 (−0·4 to 2·3) | |||
| Eating disorders | 1198·1 (806·7 to 1669·8) | 1 421·7 (950·5 to 1 978·6) | 18·7 (16·5 to 20·8)* | 17·1 (11·5 to 23·7) | 18·7 (12·5 to 26·0) | 9·6 (7·7 to 11·4)* | |||
| Anorexia nervosa | 584·9 (396·7 to 829·1) | 653·0 (439·3 to 929·4) | 11·7 (8·7 to 14·6)* | 8·2 (5·6 to 11·6) | 8·6 (5·8 to 12·2) | 4·6 (1·8 to 7·4)* | |||
| Bulimia nervosa | 613·3 (394·9 to 892·6) | 768·7 (493·0 to 1113·8) | 25·3 (23·2 to 27·6)* | 8·8 (5·7 to 12·9) | 10·1 (6·5 to 14·6) | 14·2 (12·2 to 16·2)* | |||
| Autistic spectrum disorders | 8949·8 (5978·1 to 12 300·4) | 10 051·5 (6718·9 to 13 804·4) | 12·3 (11·9 to 12·8)* | 134·7 (90·1 to 185·0) | 135·5 (90·6 to 186·0) | 0·6 (0·2 to 0·9)* | |||
| Autism | 5632·7 (3617·2 to 7920·0) | 6335·9 (4070·1 to 8919·0) | 12·5 (11·9 to 13·1)* | 84·8 (54·5 to 119·2) | 85·4 (54·9 to 120·3) | 0·7 (0·2 to 1·2)* | |||
| Asperger syndrome and other autistic spectrum disorders | 3317·1 (2204·2 to 4849·0) | 3715·6 (2467·7 to 5435·2) | 12·0 (11·5 to 12·5)* | 49·9 (33·2 to 72·9) | 50·1 (33·3 to 73·2) | 0·3 (−0·1 to 0·7) | |||
| Attention-deficit hyperactivity disorder | 617·9 (368·9 to 946·0) | 620·1 (369·8 to 948·7) | 0·4 (−0·6 to 1·2) | 8·6 (5·1 to 13·2) | 8·3 (5·0 to 12·7) | −3·5 (−4·4 to −2·8)* | |||
| Conduct disorder | 5740·5 (3459·2 to 8923·4) | 5770·5 (3471·8 to 8956·9) | 0·5 (−0·3 to 1·4) | 78·2 (47·2 to 121·3) | 79·3 (47·7 to 123·1) | 1·4 (0·7 to 2·0)* | |||
| Idiopathic developmental intellectual disability | 3119·9 (1386·3 to 5416·5) | 3442·1 (1503·1 to 5999·6) | 10·3 (8·2 to 11·4)* | 46·0 (20·4 to 80·0) | 46·2 (20·1 to 80·5) | 0·2 (−1·5 to 1·2) | |||
| Other mental and substance use disorders | 8095·9 (5632·9 to 10919·3) | 9613·4 (6698·4 to 12966·0) | 18·7 (17·7 to 19·8)* | 128·4 (89·5 to 172·8) | 128·8 (89·8 to 173·6) | 0·3 (−0·6 to 1·1) | |||
| Diabetes, urogenital, blood, and endocrine diseases | 122 917·1 (106 347·2 to 142 775·0) | 146 780·6 (126 480·8 to 171 189·3) | 19·4 (16·4 to 22·5)* | 2123·6 (1847·2 to 2453·9) | 2086·8 (1803·2 to 2422·8) | −1·7 (−4·0 to 0·6) | |||
| Diabetes mellitus | 49 724·5 (41 868·2 to 58 982·1) | 64 134·5 (53 489·7 to 76 112·8) | 29·0 (26·2 to 31·7)* | 911·2 (772·1 to 1 076·0) | 925·8 (776·1 to 1 096·3) | 1·6 (−0·5 to 3·7) | |||
| Acute glomerulonephritis | 412·3 (321·1 to 459·3) | 337·9 (228·4 to 378·2) | −18·1 (−31·7 to −10·4)* | 6·9 (5·4 to 7·7) | 4·8 (3·2 to 5·3) | −30·6 (−42·4 to −24·1)* | |||
| Chronic kidney disease | 29 488·3 (26 950·4 to 31 604·2) | 35 259·7 (32 008·1 to 37 763·0) | 19·6 (16·0 to 23·2)* | 524·4 (482·1 to 561·0) | 508·8 (462·1 to 545·1) | −3·0 (−5·8 to −0·1)* | |||
| Chronic kidney disease due to diabetes mellitus | 8713·0 (7991·5 to 9466·3) | 11 258·0 (10 302·9 to 12 225·2) | 29·2 (25·9 to 32·5)* | 159·0 (146·2 to 172·6) | 163·3 (149·6 to 177·1) | 2·7 (0·2 to 5·3)* | |||
| Chronic kidney disease due to hypertension | 10 366·1 (9 400·8 to 10 985·1) | 12 737·4 (11 488·7 to 13 553·9) | 22·9 (18·6 to 27·4)* | 188·4 (172·1 to 199·7) | 186·1 (168·1 to 197·9) | −1·2 (−4·6 to 2·3) | |||
| Chronic kidney disease due to glomerulonephritis | 7720·0 (6930·5 to 8332·1) | 8136·0 (7294·2 to 8861·4) | 5·4 (1·3 to 9·3)* | 130·7 (117·3 to 140·8) | 114·6 (103·0 to 124·6) | −12·3 (−15·6 to −9·0)* | |||
| Chronic kidney disease due to other causes | 2689·3 (2208·6 to 3237·9) | 3128·3 (2517·9 to 3802·9) | 16·3 (13·1 to 19·2)* | 46·3 (37·7 to 55·8) | 44·7 (36·0 to 54·1) | −3·4 (−5·6 to −1·5)* | |||
| Urinary diseases and male infertility | 7958·9 (6720·4 to 9447·1) | 9653·3 (8096·4 to 11537·2) | 21·3 (17·2 to 24·8)* | 147·3 (123·4 to 175·7) | 142·5 (119·0 to 170·6) | −3·3 (−6·3 to −0·5)* | |||
| Interstitial nephritis and urinary tract infections | 3399·6 (3134·3 to 3743·4) | 3950·3 (3625·0 to 4408·2) | 16·2 (11·4 to 21·5)* | 60·6 (56·1 to 66·3) | 57·6 (52·8 to 63·9) | −5·0 (−9·0 to −0·3)* | |||
| Urolithiasis | 448·5 (382·6 to 535·4) | 456·1 (398·9 to 568·2) | 1·7 (−4·7 to 10·8) | 7·9 (6·7 to 9·4) | 6·5 (5·7 to 8·1) | −17·3 (−22·5 to −9·6)* | |||
| Benign prostatic hyperplasia | 2922·0 (1867·0 to 4187·6) | 3792·7 (2419·5 to 5453·5) | 29·8 (27·6 to 32·2)* | 58·6 (37·5 to 84·1) | 57·9 (37·1 to 82·9) | −1·3 (−2·8 to 0·3) | |||
| Male infertility | 141·8 (57·7 to 293·6) | 173·9 (69·7 to 365·9) | 22·7 (19·2 to 25·9)* | 2·1 (0·8 to 4·3) | 2·3 (0·9 to 4·8) | 9·8 (6·9 to 12·5)* | |||
| Other urinary diseases | 1047·1 (861·6 to 1213·3) | 1280·2 (1044·9 to 1424·5) | 22·3 (10·3 to 36·4)* | 18·2 (15·1 to 21·1) | 18·2 (14·9 to 20·2) | 0·2 (−9·9 to 11·5) | |||
| Gynaecological diseases | 9292·8 (6396·3 to 13190·5) | 10 255·1 (7 041·0 to 14 603·3) | 10·4 (9·0 to 11·7)* | 140·3 (96·5 to 199·6) | 134·9 (92·6 to 192·2) | −3·8 (−4·9 to −2·8)* | |||
| Uterine fibroids | 2212·2 (1393·2 to 3481·1) | 2452·6 (1514·9 to 3914·8) | 10·9 (8·3 to 13·1)* | 34·6 (21·7 to 54·4) | 32·4 (20·0 to 51·8) | −6·1 (−8·1 to −4·4)* | |||
| Polycystic ovarian syndrome | 514·7 (245·2 to 972·0) | 560·0 (263·4 to 1068·1) | 8·8 (4·8 to 10·9)* | 7·5 (3·6 to 14·2) | 7·4 (3·5 to 14·0) | −2·6 (−6·5 to −0·6)* | |||
| Female infertility | 275·6 (106·1 to 606·6) | 344·5 (133·4 to 748·2) | 25·0 (19·7 to 30·1)* | 4·0 (1·6 to 8·9) | 4·5 (1·7 to 9·8) | 11·7 (7·2 to 16·2)* | |||
| Endometriosis | 894·2 (580·2 to 1240·9) | 999·0 (649·1 to 1390·3) | 11·7 (10·4 to 12·9)* | 13·4 (8·7 to 18·6) | 13·0 (8·5 to 18·2) | −2·4 (−3·4 to −1·5)* | |||
| Genital prolapse | 449·1 (228·1 to 794·4) | 519·3 (258·8 to 921·5) | 15·6 (11·7 to 18·4)* | 8·0 (4·1 to 14·0) | 7·3 (3·6 to 12·9) | −8·4 (−11·8 to −5·9)* | |||
| Premenstrual syndrome | 3287·8 (2048·5 to 4917·5) | 3621·6 (2248·2 to 5435·6) | 10·2 (8·0 to 12·0)* | 48·3 (30·1 to 72·2) | 47·3 (29·4 to 71·0) | −2·0 (−3·9 to −0·4)* | |||
| Other gynaecological diseases | 1659·3 (1213·1 to 2208·2) | 1758·0 (1278·9 to 2342·6) | 6·0 (4·0 to 8·1)* | 24·6 (18·0 to 32·6) | 23·0 (16·8 to 30·6) | −6·3 (−8·1 to −4·5)* | |||
| Haemoglobinopathies and haemolytic anaemias | 20 211·2 (16 303·9 to 25 551·6) | 20 604·4 (16 002·3 to 27 392·4) | 1·9 (−11·4 to 19·6) | 301·0 (243·6 to 378·6) | 279·3 (217·4 to 370·5) | −7·2 (−18·9 to 8·7) | |||
| Thalassaemias | 1366·6 (1131·0 to 1683·8) | 1034·6 (839·9 to 1272·9) | −24·3 (−39·0 to −2·4)* | 19·8 (16·4 to 24·3) | 14·0 (11·4 to 17·2) | −29·0 (−42·6 to −9·0)* | |||
| Thalassaemias trait | 3696·4 (2473·4 to 5333·5) | 3922·2 (2605·5 to 5657·2) | 6·1 (4·8 to 7·4)* | 55·2 (36·9 to 79·6) | 53·2 (35·3 to 76·7) | −3·6 (−4·7 to −2·6)* | |||
| Sickle cell disorders | 8662·7 (6150·3 to 13061·9) | 8973·8 (5936·8 to 14752·8) | 3·6 (−23·4 to 40·6) | 124·4 (88·4 to 187·0) | 120·3 (79·7 to 197·7) | −3·3 (−28·4 to 31·4) | |||
| Sickle cell trait | 1552·9 (1049·6 to 2211·1) | 1720·3 (1153·9 to 2463·9) | 10·8 (7·3 to 13·4)* | 23·0 (15·5 to 32·7) | 23·3 (15·6 to 33·4) | 1·4 (−1·9 to 3·6) | |||
| G6PD deficiency | 1284·4 (1105·7 to 1525·4) | 1440·5 (1225·4 to 1706·3) | 12·1 (5·3 to 21·5)* | 19·8 (17·0 to 23·4) | 19·3 (16·4 to 22·9) | −2·4 (−8·4 to 5·3) | |||
| G6PD trait | 26·9 (18·4 to 37·1) | 28·0 (19·2 to 38·9) | 4·3 (0·1 to 8·8)* | 0·4 (0·3 to 0·6) | 0·4 (0·3 to 0·5) | −5·3 (−9·0 to −1·2)* | |||
| Other haemoglobinopathies and haemolytic anaemias | 3621·4 (2874·6 to 4634·1) | 3485·1 (2770·9 to 4426·5) | −3·8 (−6·2 to −1·0)* | 58·5 (47·2 to 73·7) | 48·8 (39·1 to 61·7) | −16·5 (−19·2 to −13·8)* | |||
| Endocrine, metabolic, blood, and immune disorders | 5829·0 (5157·9 to 6691·1) | 6535·7 (5812·5 to 7435·2) | 12·1 (7·6 to 17·0)* | 92·6 (82·5 to 105·6) | 90·7 (80·9 to 103·0) | −2·1 (−5·8 to 1·7) | |||
| Musculoskeletal disorders | 123 801·0 (90 494·0 to 163 616·5) | 148 986·5 (108 880·7 to 197 118·2) | 20·3 (19·4 to 21·3)* | 2082·9 (1530·5 to 2750·7) | 2065·1 (1510·9 to 2730·7) | −0·9 (−1·5 to −0·2)* | |||
| Rheumatoid arthritis | 5204·7 (3777·3 to 6833·5) | 6333·4 (4574·6 to 8332·9) | 21·7 (18·7 to 24·7)* | 90·9 (66·3 to 118·9) | 89·7 (65·0 to 117·6) | −1·3 (−3·6 to 1·2) | |||
| Osteoarthritis | 9562·5 (6666·3 to 13 106·3) | 12 886·2 (8 990·3 to 17 634·2) | 34·8 (33·6 to 36·0)* | 180·4 (125·9 to 247·2) | 187·4 (130·8 to 256·4) | 3·9 (3·0 to 4·8)* | |||
| Low back and neck pain | 80 053·5 (57 147·1 to 108 282·6) | 94 941·5 (67 745·5 to 128 118·6) | 18·6 (17·6 to 19·6)* | 1337·3 (958·3 to 1802·5) | 1309·7 (936·1 to 1765·1) | −2·1 (−2·7 to −1·4)* | |||
| Low back pain | 51 243·0 (36 375·0 to 70 714·6) | 60 074·8 (42 682·1 to 82 419·2) | 17·2 (16·4 to 18·1)* | 852·0 (605·3 to 1 176·4) | 829·5 (589·2 to 1 138·3) | −2·6 (−3·2 to −2·0)* | |||
| Neck pain | 28 810·5 (19 224·7 to 39 466·1) | 34 866·7 (23 343·7 to 47 754·3) | 21·0 (18·9 to 23·2)* | 485·3 (327·2 to 662·1) | 480·2 (322·0 to 653·6) | −1·1 (−2·3 to 0·1) | |||
| Gout | 1063·1 (719·2 to 1451·4) | 1342·8 (908·5 to 1843·8) | 26·3 (24·6 to 28·0)* | 18·9 (12·9 to 25·8) | 19·0 (12·9 to 26·1) | 0·6 (−0·3 to 1·5) | |||
| Other musculoskeletal disorders | 27 917·2 (19 404·3 to 38 408·8) | 33 482·6 (23 135·4 to 45 865·5) | 19·9 (16·7 to 23·0)* | 455·4 (316·9 to 623·9) | 459·2 (318·0 to 630·7) | 0·8 (−1·5 to 3·2) | |||
| Other non-communicable diseases | 170 032·0 (132 096·5 to 221 007·5) | 192 712·9 (148 719·0 to 251 205·4) | 13·3 (7·1 to 16·9)* | 2726·4 (2098·4 to 3558·8) | 2687·2 (2068·1 to 3508·3) | −1·4 (−6·1 to 1·4) | |||
| Congenital anomalies | 57 594·6 (49 489·5 to 69 397·4) | 58 355·3 (52 597·9 to 64 983·3) | 1·3 (−12·2 to 11·2) | 826·5 (711·2 to 994·5) | 781·1 (704·2 to 869·9) | −5·5 (−17·9 to 3·5) | |||
| Neural tube defects | 6925·7 (5218·4 to 9487·8) | 5981·2 (4589·5 to 7574·7) | −13·6 (−32·7 to 5·7) | 98·3 (74·1 to 134·8) | 79·9 (61·3 to 101·2) | −18·8 (−36·7 to −0·6)* | |||
| Congenital heart anomalies | 26 778·2 (22 186·7 to 31 821·1) | 25 706·4 (22 612·9 to 28 639·2) | −4·0 (−18·1 to 7·6) | 382·7 (316·9 to 454·7) | 343·9 (302·5 to 383·1) | −10·2 (−23·3 to 0·4) | |||
| Cleft lip and cleft palate | 355·3 (288·5 to 424·1) | 196·0 (150·8 to 259·3) | −44·8 (−54·9 to −33·7)* | 5·1 (4·1 to 6·1) | 2·6 (2·0 to 3·5) | −48·3 (−57·6 to −38·1)* | |||
| Down's syndrome | 2379·1 (1571·3 to 3712·7) | 2 401·1 (1 739·7 to 3 291·8) | 0·9 (−23·2 to 29·4) | 34·8 (23·1 to 53·9) | 32·2 (23·3 to 44·0) | −7·5 (−29·2 to 17·8) | |||
| Turner's syndrome | 6·0 (2·1 to 12·9) | 6·6 (2·4 to 14·4) | 11·4 (8·7 to 14·0)* | 0·1 (0·0 to 0·2) | 0·1 (0·0 to 0·2) | −0·1 (−2·4 to 2·3) | |||
| Klinefelter's syndrome | 1·2 (0·4 to 2·8) | 1·3 (0·5 to 3·2) | 13·5 (10·6 to 15·6)* | 0·0 (0·0 to 0·0) | 0·0 (0·0 to 0·0) | 0·2 (−2·2 to 2·0) | |||
| Other chromosomal abnormalities | 2110·0 (1124·3 to 4575·8) | 2354·5 (1418·6 to 3905·9) | 11·6 (−19·2 to 35·1) | 30·4 (16·4 to 65·4) | 31·5 (19·0 to 52·2) | 3·6 (−24·3 to 25·0) | |||
| Other congenital anomalies | 19 039·2 (16 026·4 to 23 290·1) | 21 708·1 (18 750·6 to 25 714·7) | 14·0 (0·3 to 26·3)* | 275·0 (231·4 to 336·5) | 291·0 (251·2 to 344·6) | 5·8 (−6·6 to 16·7) | |||
| Skin and subcutaneous diseases | 42 069·1 (27 826·1 to 62 299·6) | 47 222·7 (31 372·1 to 69 571·8) | 12·3 (11·5 to 13·2)* | 639·6 (426·1 to 942·5) | 643·4 (428·2 to 946·7) | 0·6 (0·1 to 1·2)* | |||
| Dermatitis | 7733·8 (5244·5 to 10760·5) | 8788·0 (5957·2 to 12275·5) | 13·6 (12·9 to 14·4)* | 117·8 (80·2 to 164·1) | 119·7 (81·3 to 166·6) | 1·6 (1·0 to 2·2)* | |||
| Psoriasis | 5478·8 (3816·1 to 7443·3) | 6438·3 (4487·4 to 8755·9) | 17·5 (16·6 to 18·4)* | 87·4 (60·9 to 118·7) | 87·9 (61·3 to 119·5) | 0·6 (0·0 to 1·2) | |||
| Cellulitis | 406·1 (251·0 to 550·4) | 498·2 (315·1 to 692·8) | 22·7 (11·9 to 34·6)* | 6·9 (4·3 to 9·4) | 7·0 (4·5 to 9·8) | 1·6 (−7·4 to 11·6) | |||
| Pyoderma | 1070·5 (714·3 to 1585·5) | 1361·7 (932·3 to 2020·6) | 27·2 (17·0 to 38·8)* | 17·5 (11·7 to 25·6) | 19·1 (13·1 to 28·2) | 9·2 (0·6 to 18·9)* | |||
| Scabies | 4944·3 (2786·4 to 8050·4) | 5268·9 (2947·0 to 8616·4) | 6·6 (3·8 to 9·5)* | 73·0 (41·2 to 118·8) | 71·1 (39·8 to 116·0) | −2·5 (−4·5 to −0·5)* | |||
| Fungal skin diseases | 2457·6 (976·3 to 5214·9) | 2783·3 (1101·3 to 5914·6) | 13·3 (12·4 to 14·1)* | 37·2 (14·7 to 79·0) | 37·8 (15·0 to 80·3) | 1·7 (1·4 to 2·0)* | |||
| Viral skin diseases | 4977·3 (3147·1 to 7362·6) | 5396·9 (3412·0 to 7962·7) | 8·4 (7·9 to 9·0)* | 73·7 (46·7 to 109·3) | 73·0 (46·2 to 107·9) | −1·0 (−1·4 to −0·6)* | |||
| Acne vulgaris | 6553·4 (3137·7 to 12159·0) | 6854·0 (3271·3 to 12744·4) | 4·6 (3·5 to 5·7)* | 91·1 (43·7 to 169·0) | 91·9 (43·9 to 171·0) | 0·8 (−0·1 to 1·8) | |||
| Alopecia areata | 610·5 (376·1 to 911·7) | 695·6 (427·5 to 1035·9) | 13·9 (13·1 to 14·7)* | 9·4 (5·8 to 14·0) | 9·3 (5·7 to 13·8) | −1·0 (−1·7 to −0·4)* | |||
| Pruritus | 631·4 (306·3 to 1152·1) | 741·6 (359·8 to 1349·6) | 17·5 (15·5 to 19·4)* | 10·1 (4·9 to 18·5) | 10·2 (4·9 to 18·6) | 0·5 (−0·7 to 1·7) | |||
| Urticaria | 3718·5 (2297·3 to 5286·3) | 4115·7 (2560·6 to 5836·2) | 10·7 (9·5 to 12·0)* | 55·5 (34·5 to 78·7) | 55·5 (34·6 to 78·7) | 0·0 (−0·5 to 0·4) | |||
| Decubitus ulcer | 494·1 (328·7 to 602·5) | 609·1 (415·1 to 738·7) | 23·3 (17·3 to 33·2)* | 9·8 (6·5 to 11·9) | 9·4 (6·4 to 11·3) | −4·3 (−8·9 to 3·7)* | |||
| Other skin and subcutaneous diseases | 2992·7 (1486·8 to 5413·5) | 3671·3 (1817·7 to 6638·7) | 22·7 (21·9 to 23·5)* | 50·2 (24·9 to 90·8) | 51·5 (25·5 to 93·2) | 2·6 (2·1 to 3·3)* | |||
| Sense organ diseases | 54 708·4 (38 076·6 to 75 346·3) | 68 515·2 (47 752·5 to 94 246·6) | 25·2 (24·2 to 26·4)* | 993·6 (694·9 to 1 361·8) | 999·9 (697·1 to 1 370·3) | 0·6 (−0·1 to 1·3) | |||
| Glaucoma | 388·4 (268·1 to 538·9) | 541·3 (369·5 to 748·0) | 39·4 (37·0 to 41·9)* | 8·0 (5·5 to 11·2) | 8·4 (5·7 to 11·6) | 4·3 (2·6 to 5·8)* | |||
| Cataract | 3091·3 (2213·8 to 4152·6) | 3879·7 (2766·1 to 5232·4) | 25·5 (24·1 to 26·9)* | 62·9 (45·1 to 84·3) | 60·3 (43·0 to 81·0) | −4·2 (−5·2 to −3·2)* | |||
| Macular degeneration | 313·2 (219·5 to 429·6) | 462·4 (327·4 to 633·5) | 47·7 (45·2 to 49·9)* | 6·9 (4·9 to 9·5) | 7·4 (5·2 to 10·1) | 6·9 (5·3 to 8·6)* | |||
| Refraction and accommodation disorders | 12 046·9 (7737·6 to 18 905·4) | 14 593·8 (9388·5 to 22 942·4) | 21·1 (20·2 to 22·1)* | 207·8 (133·9 to 326·0) | 207·3 (133·7 to 324·8) | −0·3 (−0·9 to 0·4) | |||
| Age-related and other hearing loss | 32 119·0 (21 992·4 to 44 438·1) | 40 596·8 (27 842·2 to 56 168·9) | 26·4 (24·6 to 28·3)* | 589·4 (405·6 to 817·1) | 595·9 (409·6 to 825·0) | 1·1 (0·0 to 2·1) | |||
| Other vision loss | 1352·0 (957·1 to 1852·2) | 1756·4 (1247·4 to 2393·6) | 29·9 (27·8 to 32·1)* | 23·9 (17·0 to 32·5) | 25·2 (17·9 to 34·1) | 5·6 (4·3 to 6·7)* | |||
| Other sense organ diseases | 5397·7 (3358·7 to 7841·8) | 6684·7 (4178·4 to 9722·8) | 23·8 (22·9 to 24·8)* | 94·7 (59·3 to 137·2) | 95·5 (59·9 to 138·6) | 0·9 (0·2 to 1·5)* | |||
| Oral disorders | 13 868·2 (8387·2 to 21 285·6) | 16 969·6 (10 280·0 to 26 059·7) | 22·4 (21·6 to 23·2)* | 241·3 (147·2 to 367·9) | 240·8 (146·9 to 367·8) | −0·2 (−0·5 to 0·1) | |||
| Deciduous caries | 141·4 (61·3 to 279·6) | 147·2 (62·8 to 292·3) | 4·1 (1·6 to 5·9)* | 2·1 (0·9 to 4·1) | 2·0 (0·9 to 4·0) | −2·7 (−4·9 to −0·8)* | |||
| Permanent caries | 1536·3 (681·5 to 2960·1) | 1743·4 (773·5 to 3358·0) | 13·5 (12·6 to 14·4)* | 23·7 (10·5 to 45·7) | 23·6 (10·5 to 45·5) | −0·4 (−1·2 to 0·4) | |||
| Periodontal diseases | 2808·4 (1084·9 to 5841·7) | 3520·7 (1357·6 to 7337·3) | 25·4 (24·1 to 26·5)* | 48·0 (18·6 to 100·0) | 48·6 (18·8 to 101·2) | 1·2 (0·6 to 1·8)* | |||
| Edentulism and severe tooth loss | 5999·5 (4012·3 to 8293·2) | 7640·3 (5092·8 to 10572·8) | 27·3 (26·9 to 27·7)* | 114·6 (76·7 to 158·5) | 113·6 (76·0 to 157·3) | −0·8 (−1·1 to −0·6)* | |||
| Other oral disorders | 3382·7 (2093·2 to 5085·7) | 3918·1 (2423·4 to 5894·1) | 15·8 (15·3 to 16·4)* | 53·0 (32·8 to 79·5) | 53·0 (32·8 to 79·6) | 0·0 (−0·2 to 0·3) | |||
| Sudden infant death syndrome | 1791·7 (1458·5 to 2904·4) | 1650·1 (1366·4 to 2367·7) | −7·9 (−23·0 to 8·9) | 25·5 (20·7 to 41·3) | 22·0 (18·2 to 31·6) | −13·5 (−27·7 to 2·3) | |||
| Injuries | 263 084·3 (245 566·5 to 278 621·5) | 249 791·3 (231 409·2 to 266 419·2) | −5·1 (−8·5 to −0·9)* | 4044·0 (3764·8 to 4300·1) | 3376·1 (3120·8 to 3607·0) | −16·5 (−19·4 to −13·0)* | |||
| Transport injuries | 77 146·4 (73 768·7 to 80 734·9) | 72 365·5 (68 372·4 to 76 237·9) | −6·2 (−11·1 to −1·8)* | 1175·5 (1121·9 to 1231·3) | 971·4 (917·0 to 1024·0) | −17·4 (−21·6 to −13·5)* | |||
| Road injuries | 71 941·1 (68 596·1 to 75 312·5) | 67 270·4 (63 538·6 to 70 859·9) | −6·5 (−11·4 to −2·2)* | 1095·3 (1042·8 to 1145·8) | 903·0 (854·0 to 951·5) | −17·6 (−21·8 to −13·8)* | |||
| Pedestrian road injuries | 27 185·9 (25 567·5 to 29 487·1) | 24 491·1 (22 747·9 to 26 770·6) | −9·9 (−16·4 to −3·8)* | 417·2 (392·7 to 452·1) | 330·1 (307·3 to 360·7) | −20·9 (−26·5 to −15·5)* | |||
| Cyclist road injuries | 3721·2 (3357·8 to 4119·6) | 3399·8 (3022·9 to 3807·0) | −8·6 (−15·1 to −2·1)* | 58·5 (52·7 to 65·1) | 46·3 (41·1 to 52·0) | −20·9 (−26·3 to −15·4)* | |||
| Motorcyclist road injuries | 13 655·4 (12 181·3 to 14 651·4) | 13 686·2 (12 440·3 to 15 369·7) | 0·2 (−7·8 to 10·6) | 204·9 (182·3 to 219·9) | 182·4 (165·7 to 204·3) | −10·9 (−17·9 to −1·7)* | |||
| Motor vehicle road injuries | 26 257·7 (24 307·0 to 28 943·8) | 24 460·3 (22 362·4 to 26 719·4) | −6·8 (−11·6 to −1·8)* | 397·6 (368·7 to 437·0) | 327·5 (299·3 to 357·3) | −17·6 (−21·8 to −13·2)* | |||
| Other road injuries | 1120·9 (782·6 to 1331·6) | 1233·1 (858·6 to 1446·6) | 10·0 (−5·2 to 31·3) | 17·1 (12·1 to 20·2) | 16·6 (11·6 to 19·4) | −2·9 (−16·0 to 15·4) | |||
| Other transport injuries | 5205·3 (4772·9 to 5728·4) | 5095·1 (4507·0 to 5967·9) | −2·1 (−10·5 to 7·5) | 80·2 (73·6 to 88·4) | 68·4 (60·6 to 80·2) | −14·7 (−21·8 to −6·7)* | |||
| Unintentional injuries | 118 001·9 (105 534·5 to 129 998·5) | 107 990·9 (95 660·4 to 120 900·3) | −8·5 (−11·9 to −3·4)* | 1840·5 (1642·4 to 2033·1) | 1481·0 (1310·3 to 1660·5) | −19·5 (−22·2 to −15·3)* | |||
| Falls | 23 912·3 (20 767·3 to 27 587·9) | 26 101·6 (22 363·6 to 30 779·5) | 9·2 (3·6 to 14·6)* | 403·3 (349·6 to 467·0) | 368·3 (315·1 to 435·0) | −8·7 (−13·1 to −4·4)* | |||
| Drowning | 24 207·3 (20 715·5 to 25 812·8) | 17 864·3 (15 792·7 to 19 306·8) | −26·2 (−30·6 to −20·0)* | 356·2 (305·1 to 379·5) | 241·1 (213·0 to 260·6) | −32·3 (−36·3 to −26·7)* | |||
| Fire, heat, and hot substances | 11 737·6 (9 928·4 to 12 948·0) | 10 274·1 (8 701·9 to 11 443·4) | −12·5 (−17·4 to −5·1)* | 179·7 (153·4 to 198·0) | 139·0 (117·7 to 155·0) | −22·6 (−26·8 to −16·6)* | |||
| Poisonings | 5746·4 (3978·7 to 7215·7) | 4866·9 (3240·1 to 6070·3) | −15·3 (−28·9 to 3·6) | 86·6 (60·4 to 107·8) | 65·5 (43·6 to 81·5) | −24·4 (−36·0 to −7·5)* | |||
| Exposure to mechanical forces | 13 753·4 (12 020·2 to 15 236·7) | 13 118·4 (10 878·2 to 14 847·6) | −4·6 (−11·8 to 1·7) | 210·2 (183·6 to 234·3) | 177·4 (146·9 to 201·3) | −15·6 (−21·7 to −10·2)* | |||
| Unintentional firearm injuries | 1655·9 (1188·2 to 1837·5) | 1546·4 (1101·5 to 1727·2) | −6·6 (−11·9 to −0·6)* | 24·9 (18·0 to 27·6) | 20·7 (14·8 to 23·1) | −16·8 (−21·4 to −11·8)* | |||
| Unintentional suffocation | 2647·9 (2075·2 to 3023·5) | 2495·6 (1885·3 to 2883·4) | −5·8 (−17·6 to 7·8) | 39·3 (30·8 to 44·8) | 33·9 (25·7 to 39·1) | −13·7 (−24·3 to −1·8)* | |||
| Other exposure to mechanical forces | 9449·6 (8051·7 to 10717·9) | 9076·5 (7327·9 to 10524·0) | −3·9 (−11·4 to 3·1) | 146·0 (124·4 to 166·3) | 122·8 (99·1 to 142·7) | −15·9 (−22·2 to −10·1)* | |||
| Adverse effects of medical treatment | 5671·1 (4245·4 to 6758·2) | 5384·9 (4213·4 to 6360·5) | −5·0 (−10·5 to 2·7) | 89·8 (67·8 to 106·9) | 74·1 (58·2 to 87·7) | −17·4 (−21·6 to −11·7)* | |||
| Animal contact | 6453·3 (4501·0 to 7223·6) | 5661·2 (3760·0 to 7514·8) | −12·3 (−19·9 to 10·9) | 97·6 (68·4 to 109·2) | 76·6 (50·8 to 101·5) | −21·5 (−28·2 to −0·7)* | |||
| Venomous animal contact | 5306·6 (3504·8 to 5989·8) | 4648·0 (2901·8 to 6463·8) | −12·4 (−20·6 to 12·9) | 80·1 (53·1 to 90·4) | 62·8 (39·2 to 87·3) | −21·6 (−29·0 to 1·1) | |||
| Non-venomous animal contact | 1146·7 (920·0 to 1358·6) | 1013·2 (840·1 to 1180·4) | −11·6 (−20·1 to 5·0) | 17·5 (14·1 to 20·6) | 13·8 (11·4 to 16·1) | −21·2 (−28·5 to −6·9)* | |||
| Foreign body | 8668·4 (6684·4 to 10942·0) | 8244·8 (6786·9 to 9635·2) | −4·9 (−14·1 to 4·8) | 132·2 (103·4 to 165·2) | 112·4 (92·8 to 131·1) | −15·0 (−22·5 to −7·3)* | |||
| Pulmonary aspiration and foreign body in airway | 6632·4 (4907·7 to 8950·1) | 6321·8 (5088·3 to 7704·2) | −4·7 (−15·7 to 6·1) | 101·0 (76·1 to 134·5) | 86·2 (69·6 to 104·7) | −14·7 (−23·9 to −6·2)* | |||
| Foreign body in eyes | 48·8 (20·8 to 87·9) | 56·2 (24·0 to 101·1) | 15·2 (13·8 to 16·7)* | 0·8 (0·3 to 1·4) | 0·8 (0·3 to 1·4) | 0·5 (−0·9 to 1·3) | |||
| Foreign body in other body part | 1987·3 (1331·1 to 2717·2) | 1866·9 (1394·9 to 2247·3) | −6·1 (−19·8 to 6·4) | 30·4 (20·8 to 41·4) | 25·4 (19·1 to 30·6) | −16·4 (−28·8 to −6·5)* | |||
| Environmental heat and cold exposure | 4503·5 (3641·3 to 5457·2) | 4234·7 (3350·6 to 5294·9) | −6·0 (−10·1 to −1·4)* | 74·1 (59·9 to 89·9) | 58·7 (46·4 to 73·6) | −20·7 (−24·0 to −17·1)* | |||
| Other unintentional injuries | 13 348·6 (11 406·7 to 15 619·1) | 12 240·0 (10 234·9 to 14 692·0) | −8·3 (−12·9 to −3·8)* | 210·9 (178·2 to 249·5) | 167·9 (139·9 to 202·4) | −20·4 (−24·1 to −16·6)* | |||
| Self-harm and interpersonal violence | 58 615·7 (52 794·8 to 60 379·5) | 55 719·4 (50 909·8 to 58 127·7) | −4·9 (−9·0 to −0·8)* | 889·6 (801·0 to 916·0) | 741·1 (676·7 to 773·2) | −16·7 (−20·3 to −13·0)* | |||
| Self-harm | 35 819·1 (31 467·1 to 37 112·4) | 34 260·9 (30 852·1 to 36 042·4) | −4·4 (−10·4 to 1·6) | 551·9 (484·7 to 571·2) | 457·9 (412·2 to 481·5) | −17·0 (−22·3 to −11·9)* | |||
| Interpersonal violence | 22 796·5 (20 747·8 to 23 566·7) | 21 458·5 (19 354·8 to 22 540·1) | −5·9 (−9·0 to −2·0)* | 337·6 (308·1 to 349·1) | 283·3 (255·6 to 297·4) | −16·1 (−18·8 to −12·7)* | |||
| Assault by firearm | 8856·3 (7747·9 to 9172·1) | 9188·1 (7854·5 to 9689·2) | 3·7 (0·0 to 8·2) | 129·0 (113·0 to 133·6) | 120·7 (103·2 to 127·3) | −6·4 (−9·9 to −2·4)* | |||
| Assault by sharp object | 5425·2 (5050·4 to 5731·6) | 4546·1 (4223·1 to 4937·8) | −16·2 (−20·6 to −11·2)* | 80·5 (75·1 to 85·0) | 59·9 (55·6 to 65·0) | −25·6 (−29·6 to −21·2)* | |||
| Assault by other means | 8515·1 (7723·3 to 9065·4) | 7724·3 (6927·0 to 8395·8) | −9·3 (−14·2 to −2·7)* | 128·2 (116·6 to 136·2) | 102·7 (92·2 to 111·6) | −19·8 (−24·2 to −14·1)* | |||
| Forces of nature, war, and legal intervention | 9320·3 (6951·1 to 11 778·4) | 13 715·5 (8561·9 to 18 537·5) | 47·2 (−1·9 to 100·5) | 138·4 (103·8 to 174·8) | 182·6 (114·4 to 246·3) | 31·9 (−11·6 to 79·5) | |||
| Exposure to forces of nature | 6203·9 (4037·7 to 8412·0) | 1435·5 (1092·6 to 1846·4) | −76·9 (−81·2 to −69·4)* | 91·9 (60·2 to 124·2) | 19·6 (14·9 to 25·2) | −78·7 (−82·7 to −72·0)* | |||
| Collective violence and legal intervention | 3116·4 (2504·2 to 3760·8) | 12 279·9 (7208·0 to 17 075·2) | 294·0 (175·8 to 394·3)* | 46·5 (37·4 to 56·1) | 163·0 (95·9 to 226·4) | 250·5 (144·1 to 341·2)* | |||
Data in parentheses are 95% uncertainty intervals. DALYs=disability-adjusted life-years. G6PD=glucose-6-phosphate dehydrogenase.
*
Percentage changes that are statistically significant.