Table 2. Risk factors for 30-day mortality from the development cohort: bivariate analysis.

Risk factor	Unit	Hazard ratio (95% CI)	P-value
Gender	Man	1.56 (1.15–2.10)	0.004
Age (years)	+10	1.06 (0.97–1.16)	0.188
Pulse (per min)	+10	1.17 (1.10–1.24)	<0.001
Body temperature (°C)	+1	1.38 (1.18–1.61)	<0.001
Systolic blood pressure (mmHg)	−5	1.03 (1.0–1.05)	0.043
Diastolic blood pressure (mmHg)	−5	1.03 (0.99–1.08)	0.135
Respiratory rate (breaths/min)	+5	1.44 (1.32–1.57)	<0.001
Peripheral oxygen saturation (%)	−5	1.57 (1.47–1.68)	<0.001
Duration of illness (days)	+5	0.78 (0.60–1.0)	0.053
Glasgow Coma Score	−1	1.35 (1.30–1.40)	<0.001
Cardiopulmonary resuscitation	Yes	16.63 (5.3–52.19)	<0.001
Mechanical ventilation	Yes	13.22 (8.63–20.26)	<0.001
Admitted intensive care unit	Yes	17.90 (13.09–24.49)	<0.001
Functional status
Independent	Yes	1.0 (reference)
Partially dependent	Yes	1.24 (0.78–1.97)	0.355
Completely dependent	Yes	2.38 (1.37–4.12)	0.002
Immunocompromised by agent	Yes	1.29 (0.48–3.47)	0.617
Lymphoma	Yes	3.55 (0.50–25.36)	0.206
Leukemia or myeloma	Yes	2.92 (0.93–9.16)	0.065
Cancer	Yes	2.48 (1.02–6.03)	0.046
Chronic renal failure	Yes	1.34 (0.71–2.53)	0.371
Chronic respiratory failure	Yes	2.01 (1.25–3.24)	0.004
Cirrhosis with ascites	Yes	2.02 (1.07–3.83)	0.031
Heart failure	Yes	2.55 (1.66–3.92)	<0.001
Diabetes mellitus	Yes	1.47 (1.09–1.99)	0.012
Haemoglobin (g/dL)	−1	1.06 (1.0–1.12)	0.049
Leukocyte (x 103/μL)	+1	1.01 (1.0–1.02)	<0.001
Platelet (x 103/ μL)	−10	1.03 (1.02–1.05)	<0.001
Serum urea (mmol/L)	+5	1.16 (1.10–1.21)	<0.001
Glycaemia (mmol/L)	+5	1.30 (1.20–1.42)	<0.001
Serum creatinine (μmol/L)	+20	1.01 (1.01–1.02)	0.003
Serum albumin (g/L)	−5	1.34 (1.22–1.48)	<0.001
AST (UI/L)	+20	1.008 (1.005–1.012)	<0.001
ALT (UI/L)	+20	1.02 (1.02–1.03)	<0.001
hsCRP (mg/dL)	+5	1.37 (1.25–1.49)	<0.001
A1c (%)	+1	1.07 (1.0–1.15)	0.058

AST, aspartate aminotransferase. ALT, alanine aminotransferase. hsCRP, high-sensitivity C-reactive protein. A1c, glycated haemoglobin.