Table 1. Representative miR-518b target genes that were previously reported to associate with pregnancy-related disorders.
| Gene symbol | Gene name | Fold change | Pregnancy-related disorders | References |
|---|---|---|---|---|
| Down-regulated target genes | ||||
| TH | Tyrosine hydroxylase | 2.964 | PE | 20 |
| HSD3B1 | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | 2.572 | PE | 21,22 |
| EDNRA | Endothelin receptor type A | 2.639 | PE, FGR | 23,24 |
| AGER | Advanced glycosylation end product-specific receptor | 2.220 | PE, FGR | 25,26 |
| WNT2 | Wingless-type MMTV integration site family member 2 | 2.116 | PE, FGR | 27, 28, 29 |
| C9 | Complement component 9 | 2.073 | PE, FGR | 30 |
| TRPM2 | Transient receptor potential cation channel, subfamily M, member 2 | 2.042 | PE, FGR | 31,32 |
| Up-regulated target genes | ||||
| CD69 | CD69 molecule | 3.179 | PE, FGR | 33,34 |
| HPX | Hemopexin | 2.721 | PE | 35 |
| SERPINB2 | Serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 2.248 | PE | 36 |
| LPA | Lipoprotein, Lp(a) | 2.201 | PE | 37 |
| TNFSF10 | Tumour necrosis factor (ligand) superfamily, member 10 | 2.113 | PE | 38 |
| STC1 | Stanniocalcin 1 | 2.039 | PE, FGR | 39 |
PE: preeclampsia, FGR: foetal growth restriction.