TABLE 2.
Effect of mgrA overexpression on susceptibility to NorA substrates
| Drug | MIC (μg/ml) for strain and plasmidb:
|
|||||||
|---|---|---|---|---|---|---|---|---|
| SH1000
|
SA-K2124a
|
ISP794
|
Newman
|
|||||
| pCU1 | pK404 | pCU1 | pK404 | pCU1 | pK404 | pCU1 | pK404 | |
| Acriflavine | 12.5 | 6.25 (2) | 6.25 | 6.25 | 3.13 | 3.13 | 6.25 | 6.25 |
| BACc | 1.25 | 1.25 | 0.63 | 0.63 | 0.63 | 0.63 | 1.25 | 1.25 |
| Cetrimide | 0.31 | 0.31 | 0.31 | 0.31 | 0.31 | 0.16 (2) | 0.63 | 0.16 (4) |
| Ethidium bromide | 6.25 | 6.25 | 3.13 | 3.13 | 1.56 | 1.56 | 6.25 | 3.13 (2) |
| Norfloxacin | 1.25 | 0.63 (2) | 0.63 | 0.63 | 0.63 | 0.31 (2) | 0.31 | 0.16 (2) |
| Rhodamine | 0.63 | 0.63 | 0.31 | 0.31 | 0.31 | 0.31 | 0.63 | 0.63 |
| TPPd | 25 | 25 | 12.5 | 12.5 | 6.25 | 3.13 (2) | 12.5 | 12.5 |
SH1000 norA::lacZ.
Numbers in parentheses are reductions (n-fold) in MICs.
BAC, benzalkonium chloride.
TPP, tetraphenylphosphonium bromide.