Table 3.
Associations between cardiac troponin I, cardiac troponin T and NT-proBNP and odds of maximum stage of AKI – excluding patients with confirmed MI
| Parameter | Number of patients | Median (IQR) | Median (IQR) | ORa (95% CI) | p value | Adjustedb ORa (95% CI) | Adjustedb p value | |
|---|---|---|---|---|---|---|---|---|
| (1) | (2) | (1) | (2) | |||||
| Cardiac troponin I | ||||||||
| Any AKI (1) vs no AKI (2) | 62 | 56 | 0.12 (0.04–0.69) | 0.02 (0.02–0.06) | 1.50 (1.22–1.85) | <0.001 | 1.31 (1.05–1.63) | 0.015 |
| Stage 3 AKI (1) vs lower stage (2) | 40 | 78 | 0.17 (0.05–1.03) | 0.03 (0.02–0.08) | 1.41 (1.19–1.68) | <0.001 | 1.25 (1.01–1.56) | 0.043 |
| Stage 3 AKI with RRT (1) vs lower stage (2) | 34 | 84 | 0.17 (0.05–1.08) | 0.04 (0.02–0.12) | 1.35 (1.14–1.60) | 0.001 | 1.12 (0.93–1.45) | 0.199 |
| Cardiac troponin T | ||||||||
| Any AKI (1) vs no AKI (2) | 62 | 56 | 0.07 (0.03–0.15) | 0.02 (0.01–0.04) | 1.83 (1.42–2.35) | <0.001 | 1.55 (1.16–2.07) | 0.003 |
| Stage 3 AKI (1) vs lower stage (2) | 40 | 78 | 0.08 (0.04–0.19) | 0.03 (0.01–0.06 | 1.69 (1.32–2.15) | <0.001 | 1.51 (1.10–2.09) | 0.012 |
| Stage 3 AKI with RRT (1) vs lower stage (2) | 34 | 84 | 0.08 (0.05–0.18) | 0.03 (0.01–0.07) | 1.55 (1.23–1.96) | <0.001 | 1.31 (0.94–1.84) | 0.109 |
| NT-proBNP | ||||||||
| Any AKI (1) vs no AKI (2) | 62 | 56 | 7182 (2314–15,550) | 1055 (192–2944) | 1.47 (1.24–1.74) | <0.001 | 1.31 (1.06–1.61) | 0.012 |
| Stage 3 AKI (1) vs lower stage (2) | 40 | 78 | 9179 (2561–16,179) | 1609 (320–6015) | 1.49 (1.23–1.81) | <0.001 | 1.45 (1.12–1.86) | 0.004 |
| Stage 3 AKI with RRT (1) vs lower stage (2) | 34 | 84 | 10,105 (2617–17,069) | 1681 (490–6416) | 1.48 (1.21–1.81) | <0.001 | 1.43 (1.09–1.88) | 0.011 |
AKI acute kidney injury, RRT renal replacement therapy, IQR interquartile range, CI confidence interval, MI myocardial infarction, NT-proBNP N-terminal pro-brain natriuretic peptide, OR odds ratio, APACHE Acute Physiology and Chronic Health Evaluation
aORs estimated using logistic regression models with troponin levels log2 transformed. ORs represent the change in odds of AKI associated with a doubling of troponin levels
bAdjusted for age, APACHE II score, gender, hypertension, diabetes, ischaemic heart disease, sepsis, lactate, bilirubin and cumulative fluid balance in the first 24 hours in the ICU (reduced to three principal components in models)