TABLE 2.
S. aureus density in target tissues with antibiotic treatment in the rat endocarditis model
| Group (no. of animals) | Mean log10 CFU/g of tissue ± SDa in:
|
||
|---|---|---|---|
| Vegetation | Kidney | Spleen | |
| Untreated control (8) | 9.93 ± 0.53 | 7.14 ± 0.53 | 6.44 ± 0.63 |
| Vancomycin (6) | 6.03 ± 1.30** | 3.84 ± 1.32** | 4.26 ± 0.92** |
| Vancomycin relapse (5) | 8.27 ± 0.65 | 5.23 ± 0.94* | 5.50 ± 0.83 |
| Cefazolin (5) | 8.80 ± 0.97* | 5.12 ± 1.40* | 4.39 ± 0.97* |
| Gentamicin (5) | 9.41 ± 0.53 | 5.37 ± 0.58** | 5.14 ± 0.65* |
a
SD, standard deviation. P < 0.05 with respect to control; P < 0.005 with respect to control.