FIG. 6.

Control of GBS colonization in mice with PlyGBS. (a) Mice were colonized with GBS vaginally after synchronization with β-estradiol valerate. One day after GBS inoculation, two groups of mice were treated vaginally with either buffer (n = 15) or PlyGBS (n = 15). Each mouse was swabbed vaginally before treatment (0-h samples) and after treatment at 2- to 4-h intervals (2- and 4-h samples). (b) Mice were colonized with GBS in their upper respiratory tract, and 1 day later they were treated with either buffer (n = 18) or PlyGBS (n = 20). Each mouse was swabbed before (0 h) and after treatment (2 and 24 h). After transformed into log₁₀, the colony counts of oropharynx samples were averaged for each time interval in the same group and plotted. Error bars represent the standard error of the mean.