TABLE 2.
In vitro antifungal activity of R-135853 against clinical yeast isolates
| Organism (no. of isolates) and agent | MIC (μg/ml)
|
||
|---|---|---|---|
| Range | 50% | 90% | |
| Candida albicans, FLC-Sa (22) | |||
| R-135853 | 0.016-0.06 | 0.03 | 0.03 |
| FLC | 0.25-8 | 1 | 2 |
| ITC | 0.008-0.03 | 0.016 | 0.03 |
| AMB | 0.12-0.25 | 0.12 | 0.12 |
| Candida albicans, FLC-S-DD and FLC-Rb (8) | |||
| R-135853 | 0.03-0.06 | —c | — |
| FLC | 16-128 | — | — |
| ITC | 0.03-0.12 | — | — |
| AMB | 0.12-0.25 | — | — |
| Candida glabrata (15) | |||
| R-135853 | 0.5-1 | 0.5 | 1 |
| FLC | 1-16 | 8 | 16 |
| ITC | 0.03-0.5 | 0.12 | 0.25 |
| AMB | 0.06-0.12 | 0.12 | 0.12 |
| Candida tropicalis (15) | |||
| R-135853 | 0.016-0.5 | 0.25 | 0.5 |
| FLC | 0.25-4 | 1 | 2 |
| ITC | 0.008-0.12 | 0.03 | 0.12 |
| AMB | 0.06-0.25 | 0.12 | 0.12 |
| Candida parapsilosis (15) | |||
| R-135853 | 2-128 | 64 | 128 |
| FLC | 0.5-4 | 1 | 2 |
| ITC | 0.016-0.25 | 0.03 | 0.03 |
| AMB | 0.03-0.25 | 0.25 | 0.25 |
| Cryptococcus neoformans (15) | |||
| R-135853 | 0.25-1 | 0.25 | 0.5 |
| FLC | 1-16 | 4 | 16 |
| ITC | 0.016-0.12 | 0.06 | 0.12 |
| AMB | 0.06-0.25 | 0.12 | 0.12 |
a
FLC MICs, ≤8 μg/ml.
b
FLC MICs, ≥16 μg/ml.
c
—, not determined.