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Pharmacokinetic parameters for R-135853 in mice
| Parameter | Oral dose (20 mg/kg) | Intravenous dose (2 mg/kg) |
|---|---|---|
| Half-life (h) in plasma | 1.1 | 0.47 |
| AUC0-∞ (μg · h/ml) | 3.19 | 0.509 |
| Total body clearance (liters/h/kg) | —a | 3.93 |
| Distribution volume (liters/kg) | — | 1.84 |
| Tmax (h) | 0.25 | — |
| Cmax (μg/ml) | 2.32 | — |
| Bioavailability (%) | 62.7 | — |
—, not determined.
