TABLE 2.
MAb treatment of mice infected with SM and MC switch variants
Infection and treatment regimen | Median days of survivala
|
||||
---|---|---|---|---|---|
SM control | SM + MAb | MC control | MC + MAb | P valueb | |
104 cells i.t. + 1 mg of MAb | 99 | 129 | 32 | 48 | 0.0018 |
105 cells i.t. + 1 mg of MAb | 53 | 53 | 29 | 32 | No difference |
106 cells i.t. + 1 mg of MAb | 59 | 76 | 31 | 38 | 0.03 |
5 × 106 cells i.p. + 0.5 mg of MAb | 3 | 10 | 4 | 3 | 0.02 |
105 cells i.p. + 0.5 mg of MAb | 39 | 45 | 4 | 5 | No difference |
n = 10 mice per treatment group.
Log rank denotes difference in survival.