Table 2.

Definition of “fast decline” based on MMSE score point decrement on time

Source	MMSE score point decrement/	Ref
	time of observation
Kinkingnéhun et al., 2008	≥6/36 months	[14]
Sona et al., 2012	≥6/first 18 months	[21]
Soto et al., 2008	≥4/first 6 months	[68]
Soto et al., 2005	≥4/6 months plus ≥1/	[69]
	6 months follow up
Soto et al., 2008	≥3/6 months	[70]
Dumont et al., 2003	≥3/6 months	[27]
O’Hara et al., 2002	≥3/12 months	[24]
Carcaillon et al., 2007	≥3/12 months	[22]
Doody et al., 2001	≥5/12 months	[20]
Schmidt et al., 2011	≥6/12 months	[71]