Table 3.
Demographic, cognitive, and functional characteristics of groups (mean±SD)
| Sample | Slow | Intermediate | Fast | ANOVA | |
| Decliners | Decliners | Decliners | |||
| Age-T0 | 77.3±6.5 | 77.1±6.3 | 78.5±7.3 | 77.4±6.9 | n.s. |
| Age of onset | 74.6±6.8 | 74.5±6.6 | 75.3±7.3 | 74.8±7.3 | n.s. |
| Age T0 minus age of onset | 2.7±2.3 | 2.6±2.2 | 3.2±2.6 | 2.6±2.6 | n.s. |
| Education (years) | 5.5±2.9 | 5.6±3.1 | 4.9±2.4 | 5.5±3.5 | n.s. |
| MMSE | |||||
| T0 | 18.4±4.5 | 18.1±4.2 | 19.2±5.6 | 19.5±4.7 | n.s. |
| T48 | 14.4±5.4 | 14.4±5.3 | 13.3±6.4 | 15.3±5.1 | n.s. |
| ADL | |||||
| T0 | 4.9±1.4 | 4.9±1.4 | 5.2±1.4 | 4.7±1.5 | n.s. |
| T48 | 2.9±1.5 | 2.9±1.6 | 2.1±1.2 | 3.1±1.3 | n.s. |
| IADL | |||||
| T0 | 3.9±2.3 | 4.2±2.3 | 4.2±2.3 | 3.2±2.2 | F [2,318] = 4.23, p < 0.05, |
| η2 = 0.026 | |||||
| T48 | 1.2±1.5 | 1.4±1.6 | 0.53±0.9 | 0.75±0.7 | F [2,152] = 3.13, p < 0.05, |
| η2 = 0.039 | |||||
| Chi-square test | |||||
| Gender | 254 F, 70 M | 183 F, 42 M | 25 F, 12 M | 46 F, 15 M | n.s. |
| Familiar history of dementia | 50/164 | 37/124 | 3/15 | 10/25 | n.s. |
| (160 m.d.) | (101 m.d.) | (22 m.d.) | (37 m.d.) | ||
| AChEI/memantine treatment | |||||
| T0 | 43/324 | 27/225 | 2/37 | 14/62 | n.s. |
| T48 | 135/154 | 105/119 | 13/15 | 17/20 | n.s. |
| (2 m.d.) | (2 m.d.) | ||||
| Antipsychotic treatment | |||||
| T0 | 4/324 | 2/225 | 1/37 | 1/62 | n.s. |
| T48 | 30/156 | 23/121 | 7/15 | 0/20 | χ2 = 12.03, p < 0.01; C = 0.268 |
SD, standard deviation; T0, baseline evaluation; T48, evaluation at 48 months; MMSE, Mini-Mental State Examination; ADL, Activities of Daily Living; IADL, Instrumental Activities of Daily Living; F, females, M, males; m.d., missing data; sig., significance; n.s., no significant differences; AChEI, acetylcholinesterase inhibitors treatment.