TABLE 3.
Mean pharmacokinetic parameters of tigecycline after various i.v. doses infused over a 1-h period q12h in the MAD study
| Tigecycline dose group (mg) | Mean Value (%CV) at:
|
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|---|---|---|---|---|---|---|---|
| Day 1
|
Day 10a
|
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| Cmax (ng/ml) | AUC0-τ (ng h/ml) | Cmax (ng/ml) | AUCss (ng h/ml) | t1/2 (h) | CL (l/h/kg) | Vss (l/kg) | |
| 25 | 261 (14) | 796 (8) | 324 (17) | 1,482 (18) | 49.3 (72) | 0.20 (17) | 8.6 (23) |
| 50 | 487 (17) | 1,440 (14) | 621 (15) | 3,069 (12) | 36.9 (32) | 0.20 (9) | 7.2 (7) |
| 100 | 816 (15) | 2,389 (13) | 1,173 (15) | 4,980 (19) | 66.5 (34) | 0.24 (20) | 9.1 (32) |
a
Day 10 values for the 100-mg tigecycline dose group are actually day 9 values.