TABLE 1.
In vitro activities of moxifloxacin, levofloxacin, gatifloxacin, and gemifloxacin, with and without 20 μg of reserpine per ml, against 14 strains of F. canifelinum
| Antimicrobial agent | Addition of reserpine | MIC (μg/ml)a
|
||
|---|---|---|---|---|
| Range | 50% of strains | 90% of strains | ||
| Moxifloxacin | + | 16-64 | 32 | 32 |
| Moxifloxacin | − | 16-64 | 32 | 32 |
| Levofloxacin | + | 16-64 | 32 | 64 |
| Levofloxacin | − | 16-64 | 32 | 64 |
| Gatifloxacin | + | 32-64 | 64 | 64 |
| Gatifloxacin | − | 32-64 | 64 | 64 |
| Gemifloxacin | + | 8-16 | 8 | 8 |
| Gemifloxacin | − | 4-16 | 8 | 8 |
a
For contrast, MICs of fluoroquinolone susceptible fusobacterial species are between 0.015 and a maximum of 4 (8).