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. 2017 Apr 12;18:69. doi: 10.1186/s13059-017-1197-z

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — H2AK121ub and H3K27me3 marks are reduced in atbmi1a/b/c mutants. a–c Metagene plot showing H2AK121ub coverage at a all marked genes, b H2AK121ub/H3K27me3-marked genes, and c only-H2AK121ub-marked genes in WT and atbmi1a/b/c mutants. d–f Metagene plot showing H3K27me3 coverage at d all marked genes, e H2AK121ub/H3K27me3-marked genes, and f only-H3K27me3-marked genes in WT and atbmi1a/b/c mutants. g WB quantification of H2AK121ub and H3K27me3 levels normalized to H3 levels in WT and atbmi1a/b/c. Error bars represent standard deviation among at least three biological replicates (see also Additional file 1: Figures S13 and S18). h, i Percentage of genes retaining different levels of h H2AK121ub and i H3K27me3 marks at peaks in atbmi1a/b/c mutants. H2AK121ub levels are indicated by the shade of red and H3K27me3 levels by the shade of blue (80–120% is considered WT levels)