TABLE 3.
Effects of stereochemistry and structure on BM0 antifungal activity
| Peptide | MIC90 (μM)a
|
IC50 (μM) for S. cerevisiae Pma1p (7.0) | |||
|---|---|---|---|---|---|
| S. cerevisiae (7.3)b | C. albicans (7.5) | C. glabrata (7.5) | C. tropicalis (7.5) | ||
| d-NH2-RFWWFRRR-CONH2 (BMO) | 0.46 | 7.3 | 7.3 | 7.3 | 2.6 |
| d-NH2-RRRFWWFR-CONH2 | 1.6 | 6.3 | 3.1 | 6.3 | 1.8 |
| l-NH2-RFWWFRRR-CONH2 | 1.9 | 31 | 15 | 7.7 | 3.8 |
| l-NH2-RRRFWWFR-CONH2 | 2.0 | 16 | 8.0 | 4.0 | 2.2 |
| d-NH2-RFWWF-CONH2 | 11 | 88 | 44 | 44 | 17 |
| d-CH3CO-RFWWFRRR-CONH2 | 2.0 | 8.0 | 8.0 | 8.0 | 5.8 |
a
MIC90, minimum concentration at which there is >90% growth inhibition compared to no-peptide control.
b
Values in parentheses are pHs.