Table 1. Composition and characteristics of nanoparticles (NP) used.
| Nanoparticle | Molar fraction of constituents | Physical characteristics | ||||
|---|---|---|---|---|---|---|
| Pluronic | PE Lipid | PFCE | Particle size | Polydispersity | Zeta Potential | |
| X | X | X | [nm] (±S.D.) | Index (±S.D.) | [mV] (±S.D.) | |
| Pluronic-Basic—PFCE NP | 0.01419 | — | 0.98581 | 186 (15) | 0.06 (0.02) | −4.81 (1.52) |
| Pluronic-(DPPE)—PFCE NP | 0.00582 | 0.00001 | 0.99417 | 246 (16) | 0.30 (0.02) | −18.55 (1.61) |
| Pluronic-(POPE 1x)—PFCE NP | 0.00580 | 0.00001 | 0.99418 | 200 (6) | 0.03 (0.01) | −12.13 (0.31) |
| Pluronic-(POPE 10x)—PFCE NP | 0.00580 | 0.00011 | 0.99408 | 200 (1) | 0.12 (0.08) | −7.37 (0.53) |
| (DSPE-PEG2000)—PFCE NP | — | 0.00006 | 0.99994 | 216 (19) | 0.20 (0.01) | −28.43 (1.33) |
Dynamic light scattering was used to measure Z-average diameter (mean diameter based on intensity of scattered light and sensitive to presence of large particles), peak diameter, peak width and polydispersity index (PdI). PFCE = perfluoro-15-crown-5-ether; X = mole fraction; PE = phosphoethanolamine; DPPE = 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine; POPE = 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine; DSPE-PEG2000 = 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N[methoxy(polyethylene glycol)-2000.