Table 3.

stratified pooled mean weight change and 95% confidence interval in women during chemotherapy treatment for early stage breast cancer

	No of estimates	Pooled weight change kg	95% CIa	I2b
Overall
All	34	2.7	2.0, 7.5	94.2
Type Chemotherapy
CMF included	20	3.5	2.7, 4.3	93.7
No CMF	14	1.4	0.7, 2.0	74.7
Menopausal status
Premenopausal	9	2.6	1.5, 3.6	86.9
Postmenopausal	2	1.3	−1.1, 3.7	89.4
Perimenopausal	1	4.8	4.5, 5.0
Combination	22	2.7	2.0, 3.4	88.3
Baseline mean BMI
20.0–24.9	6	0.5	−0.4; 1.3	45.1
25.0–29.9	15	2.4	1.8; 3.6	73.2
Unknown	13	3.5	2.6; 4.5	95.4
Follow-up				93.8
end of chemotherapy / 6 months after baseline	26	2.7	2.0; 3.5	90.9
6 months after chemotherapy / 12 months after baseline	8	2.4	1.3; 3.4
Type of study
Chart review	16	3.6	2.8, 4.4	94.8
Prospective	18	1.6	1.1, 2.2	69.5
Publication year
Before and including 2000	13	3.8	2.9, 4.7	93.3
After 2000	21	1.9	1.3, 2.5	81.6
Sample Size
≤ 100	23	3.0	2.2, 3.9	92.7
> 100	11	2.1	1.3, 2.8	90.1
Country
United States	10	2.8	1.6; 4.1	93.4
Canada	12	3.1	2.1; 4.1	91.8
Western Europe	9	2.0	1.1; 2.8	86.2
Australia	1	2.4	1.1;3.6
Turkey	1	1.7	−0.1; 3.5
Korea	1	3.6	−3.6; 10.9
Study quality
Low quality	11	2.9	1.6; 4.1	96.7
High quality	23	2.5	1.8; 3.2	88.8

^aConfidence interval

^b1² = the percentage heterogeneity due to between-study variation