TABLE 2.
Bacterial titers in vegetations after 5 days of treatment
| Regimen | Mean ± SD log10 CFU/g of vegetation (no. of animals)
|
Imipenem concn (mg/liter) | |
|---|---|---|---|
| COL | hGISA | ||
| Control | 9.1 ± 0.7 (9) | 8.6 ± 0.4 (6) | |
| Linezolid (10 mg/kg/12 h)c | 6.4 ± 1.0 (8)a | 6.1 ± 0.4 (5)a | |
| Imipenem (15 mg/kg/day) | 9.4 ± 0.4 (5) | NDd | 0.45 ± 0.2 |
| Imipenem (100 mg/kg/day) | ND | 8.0 ± 0.3 (5) | 2.30 ± 0.9 |
| Linezolid + imipenem | 3.8 ± 0.9 (6)a,b | 3.7 ± 0.5 (5)a,b | |
a
P < 0.0001 versus controls.
b
P < 0.0001 versus linezolid and imipenem treatment by Scheffe's test after analysis of variance.
c
Simulated dose for humans.
d
ND, not done.