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. 2017 Apr 12;17:260. doi: 10.1186/s12885-017-3244-2

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Frequency of gene-specific DNA methylation in tumor (T), tumor-adjacent (A) and tumor-distant (D) tissues. Light blue: methylation status < LOD, middle blue: methylation status < LOQ, dark blue: methylation status ≥ LOQ. LODs and LOQs of MS-HRM assays for APC, BRCA1, CDKN2A, ESR1, HER2/neu and PTEN are given in Table 2. The LOQ of the PSQ assay for ESR2 is 5%. Due to the low LOD and LOQ of the assay for PTEN and the low frequency of methylation in tumors, tumor-adjacent and tumor distant-tissues were analyzed only randomly