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. 2017 Apr 12;7:16. doi: 10.1186/s13578-017-0144-8

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — HBV induces the migration of cancer cells by inducing STAT3 overexpression via downregulation of miR-340-5p expression. a qRT-PCR analysis of the effect of HBV on STAT3 mRNA expression. b Western blot assays show HBV induces high levels of STAT3 expression. d Wound-healing assays show that the forced expression of miR-340-5p mimics rescue HBV-induced wound-healing ability. c, e Representative photographs of Transwell assays: d miR-340-5p mimics rescued HBV-induced cell migration. e Over expression of STAT3 rescued miR-340-5p mimics inhibition and led to a dramatic increase in cell migration. *P < 0.05; **P < 0.01; ***P < 0.001