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Indomethacin and aspirin inhibit C. pneumonia enhancement of MMP-1 and MMP-9. Monocytes were cultured for 6 h with C. pneumoniae (105/ml), washed, and cultured in the presence or absence of TNF-α plus GM-CSF and indomethacin (Indo) (1 μM) or aspirin (Asp) (1 μM) for 48 h. The levels of MMP-1 and -9 in the 48-h supernatants were determined by Western blotting.
