FIG. 1.

Cytokine production in the lungs of anti-TNF-α-treated mice. (A-C) BAL fluid was collected on days 7 and 14 postinfection and was analyzed for TNF-α, IL-12, and MCP-1/CCL2 levels by ELISA. (D) Lung leukocytes were cultured for 24 h without additional stimulation, and supernatants were collected and analyzed by ELISA for IFN-γ levels. Cytokine levels in uninfected lungs are represented by the dashed line. Results are expressed as means ± SEs. n = 8 mice/group/time point from two separate experiments. *, P < 0.05 for comparisons with control mice.