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Forced coupling of lysosomes to kinesin-1 drives lysosomes to axon tips (Figs. 4 and 5). DIV 7 neurons transfected on DIV 5 with plasmids encoding chimeric constructs comprising the motor domain of KIF5A fused to streptavidin and mCherry (mCh-KIF5A-Strep; red channel) and LAMP1 fused to the streptavidin-binding peptide and GFP (LAMP1-SBP-GFP; green channel). Arrows point to the AIS. Note the dramatic redistribution of lysosomes to axon tips (dashed circles).
