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Proposed model for the role of p97 in mediating regulated degradation of CRL4CRBN substrates, including GS and lenalidomide-induced neosubstrates. For the sake of simplicity, one subunit of GS homodecamer is ubiquitylated by CRL4CRBN, segregated by the p97–UFD1–NPL4 complex, and subsequently degraded by the proteasome upon the addition of glutamine. Ub, ubiquitin.
