Fig. S6.

(Related to Fig. 3) CRBN expression covaries significantly with p97 and its adaptors. Transcript expression values (expressed as TPM) were obtained from RNA-seq performed on cancer cell lines in the 935 CCLE. These data were generated by the CTD² network (https://ctd2.nci.nih.gov/dataPortal/) established by the National Cancer Institute’s Office of Cancer Genomics. For each detected transcript, significance of correlation with Crbn across 935 samples was determined. Data are plotted in terms of increasing significance for transcripts positively and negatively correlated with CRBN. p97 and its adaptors, as a whole, are significantly correlated with CRBN mRNA expression as determined by Kolmogorov–Smirnov testing.